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Vitamin D

Vitamin D helps the body maintain healthy levels of calcium and phosphorus.

This function of the vitamin is essential for building and maintaining healthy bones.

Of note is that calcium, which is the main element in bones, can be absorbed by the body only when vitamin D is present.

Both D vitamin and calcium are involved in many body functions, including keeping the immune and nervous systems healthy.

From anti aging perspective, interesting is that in one study conducted by the University of California in San Diego, researchers reviewed 63 old studies and found that the vitamin could reduce the chances of developing breast, ovarian and colon cancer, in some cases as much as 50%.

However, the study also acknowledged that large doses of vitamin D should be treated with caution, as damage to the liver and kidneys is possible.

On the other hand, "no other nutrient is so widely deficient in the United States," according to a interview of Meir Stampfer, MD, chair of the department of epidemiology at the Harvard School of Public Health for Prevention magazine.

Vitamin D - Studies

American Academy of Sciences. Dietary Reference Intakes: Calcium Phosphorus, Magnesium, Vitamin D, and Fluoride. National Academy Press; 1997.

Bikle DD, Halloran BP, Harris ST, Portale AA. Progestin antagonism of estrogen stimulated 1,25-dihydroxyvitamin D levels. J Clin Endocrinol Metab. 1992;75(2):519-523.

Blank RD, Bockman RS. A review of clinical trials of therapies for osteoporosis using fracture as an end point. J Clin Densitom. 1999;2(4):435-452.

Braun J, Sieper J. [Glucocorticoid-induced osteoporosis] Orthopade. 2001;30(7):444-450. German.

Brawley OW, Parnes H. Prostate cancer prevention trials in the USA. Eur J Cancer. 2000;36(10):1312-1315.

Brenner RV, Shabahang M, Schumaker LM, et al. The antiproliferation effect of vitamin D analogs on MCF-7 human breast cancer cells. Cancer Lett. 1995;92:77–82.

Chan JM, Giovannucci E, Andresson SO, Yuen J, Adami HO, Wolk A. Dairy products, calcium, phosphorous, vitamin D, and risk of prostate cancer (Sweden). Cancer Causes Control. 1998;9(6):559-566.

Clemens TL, Adams JS, Henderson SL, Holick MF. Increased skin pigment reduces the capacity of skin to synthesise vitamin D3. Lancet. 1982;1(8263):74-76.

Dawson-Hughes B, Harris SS, Dallal GE. Plasma calcidiol, season, and serum parathyroid hormone concentrations in healthy elderly men and women. Am J Clin Nutr. 1997;65:67–71.

Dawson-Hughes B, Harris SS, Krall EA, et al. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age and older. N Engl J Med. 1997;337:670–676.

Fox J. Verapamil induces PTH resistance but increases duodenal calcium absorption in rats. Am J Physiol. 1988;255(5):E702-707.

Gallagher JC, Fowler SE, Detter JR, Sherman SS. Combination treatment with estrogen and calcitriol in the prevention of age-related bone loss. J Clin Endocrin Metabol. 2001;86(8):3618-3628.

Garland CF, Garland FC, Gorham ED. Calcium and vitamin D: their potential roles in colon and breast cancer prevention. Ann NY Acad Sci. 1999;889:107-119.

Gillespie WJ, Avenell A, Henry DA, O'Connell DL, Robertson J. Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis (Cochrane Review). In: The Cochrane Library, Issue 1, 2001. Oxford: Update Software.

Giovannucci E, Rimm EB, Wolk A, et al. Calcium and fructose intake in relation to risk of prostate cancer. Cancer Res. 1998;58(3):442-447.

Gloth FM, Alam W, Hollis B. Vitamin D vs broad spectrum phototherapy in the treatment of seasonal affective disorder. J Nutr, Health Aging. 1999l3(1):5-7.

Godsall JW, Baron R, Insogna KL. Vitamin D metabolism and bone histomorphometry in a patient with antacid-induced osteomalacia. Am J Med. 1984;77(4):747-750.

Harrell CC, Kline SS. Vitamin K—supplemented snacks containing olestra: implication for patients taking warfarin [letter]. JAMA. 1999;282(12):1133-1134.

Hathcock JN. Metabolic mechanisms of drug-nutrient interactions. Fed Proc. 1985;44(1):124-129.

Hayes CE, Cantorna MT, DeLuca HF. Vitamin D and multiple sclerosis. [Review] Proc Soc Exp Biol Med. 1997;216(1):21-27.

Heikkinen AM, Tuppurainen MT, Niskanen L, et al. Long-term vitamin D3 supplementation may have adverse effects on serum lipids during menopause hormone replacement therapy. J Endocrino. 1997;137:495–502.

Henning HV. Aluminum toxicity [in German]. Klin Wochenschr. 1989;67(24):1221-1228.

Hypponen E, Laara E, Reunanen A, Jarvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet. 2001;358(9292):1500-1503.

Jänne PA, Mayer RJ. Chemoprevention of colorectal cancer. N Engl J Med. 2000;342(26):1960-1968.

Kampman E, Slattery ML, Caan B, Potter JD. Calcium, vitamin D, sunshine exposure, dairy products and colon cancer risk (United States). Cancer Causes Control. 2000:11:459-466.

Knodel LC, Talbert RL. Adverse effects of hypolipidaemic drugs. Med Toxicol. 1987;2(1):10-32.

Lane NE, Gore R, Cummings SR, et al. Serum vitamin D levels and incident changes of radiographic hip osteoarthritis. A longtitudinal study. Arthritis Rheum. 1999;42(5):854-860.

Langman M, Boyle P, et al. Chemoprevention of colorectal cancer. Gut. 1998;43:578–585.

Lansdowne AT, Provost SC. Vitamin D3 enhances mood in healthy subjects during winter. Psychopharmacology (Berl).1998;135(4):319-323

LeBoff MS, Kohlmeier L, Hurwitz S, Franklin J, Wright J, Glowacki J. Occult vitamin D deficiency in postmenopausal US women with acute hip fracture. JAMA. 1999;281:1505-1511.

Lochner JD, Schneider DJ. The relationship between tuberculosis, vitamin D, potassium and AIDS. A message for South Africa? [Afrikaans]. S Afr Med J. 1994;84(2):79-82.

Lokeshwar BL, Schwartz GG, Selzer MG, et al. Inhibition of prostate cancer metastasis in vivo: a comparison of ,23-dihydroxyvitamin D (calcitriol) and EB1089. Cancer Epidemiol Biomarkers Rev. 1999;8(3):241-248.

Martinez ME, Giovannucci EL Colditz GA, et al. Calcium, vitamin D, and the occurrence of colorectal cancer among women. JNCI. 1996;88:1375–1382.

Matsui MS, Rozovski SJ. Drug-nutrient interaction. Clin Ther. 1982;4(6):423-440.

McAlindon TE, Felson DT, Zhang Y, et al. Relation of dietary intake of serum levels of vitamin D to progression of osteoarthritis of the knee among participants in the Framingham study. Ann Intern Med. 1996;125:353-359.

McMurray DN, Bartow RA, Mintzer CL, Hernandez-Frontera E. Micronutrient status and immune function in tuberculosis. Ann NY Acad Sci. 1990;587:59-69.

National Institutes of Health, Office of Dietary Supplements. Facts About Dietary Supplements: Vitamin D. August 2001. Accessed on February 14, 2002 at http://www.cc.nih.gov/ccc/supplements/intro.html

Nutrients and Nutritional Agents. In: Kastrup EK, Hines Burnham T, Short RM, et al, eds. Drug Facts and Comparisons. St. Louis, Mo: Facts and Comparisons; 2000.

Pfeifer M, Begerow B, Minne HW, Nachtigall D, Hansen C. Effects of a short-term vitamin D(3) and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women. J Clin Endocrinol Metab. 2001;86(4):1633-1637.

Potter JD. Nutrition and colorectal cancer. Cancer Causes Control. 1996;7:127-146.

Ravid A, Rocker D, Machlenkin A, et al. 1,25-Dihydroxyvitamin D3 enhances the susceptibility of breast cancer cells to doxorubicin-induced oxidative damage. Cancer Res. 1999;59:862-867.

Reichrath J. Will analogs of 1,25-dihydroxyvitamin D(3) (calcitriol) open a new era in cancer therapy? [Review] Onkologie. 2001;24(2):128-133.

Rook GA, Steele J, Fraher L, et al. Vitamin D3, gamma interferon, and control of proliferation of Mycobacterium tuberculosis by human monocytes. Immunology. 1986;57(1):159-163.

Schumann K. Interactions between drugs and vitamins at advanced age. Int J Vitam Nutr Res. 1999;69(3):173-178.

Schlagheck TG, Riccardi KA, Zorich NL, Torri SA, Dugan LD, Peters JC. Olestra dose response on fat-soluble and water-soluble nutrients in humans. J Nutr. 1997;127(8 Suppl):1646S-1665S.

Self TH, Chrisman CR, Baciewicz AM, Bronze MS. Isoniazid drug and food interactions. Am J Med Sci. 1999;317(5):304-311.

Semba RD, Garrett E, Johnson BA, Guralnik JM, Fried LP. Vitamin D deficiency among older women with and without disability. Amer J Clin Nutr. 2000;72:1529-1534.

Sowers MF, Lachance L. Vitamins and arthritis: The roles of vitamins A, C, D, and E. Rheum Dis Clin North Am. 1999;25(2):315-331.

Staberg B, OxholmA, Klemp P, Christiansen C. Abnormal vitamin D metabolism in patients with psoriasis. Acta Derm Venereol. 1987;67(1):65-68.

Thomas MK., Lloyd-Jones DM, Thadhani RI, et al. Hypovitaminosis D in medical inpatients. N Engl J Med. 1998;338:777–783.

Thornquist MD, Kristal AR, Patterson RE, et al. Olestra consumption does not predict serum concentrations of carotenoids and fat-soluble vitamins in free-living humans: early results from the sentinel site of the olestra post-marketing surveillance study. J Nutr. 2000;130(7):1711-1718.

Valmadrid C, Voorhees C, Litt B, Schneyer CR. Practice patterns of neurologists regarding bone and mineral effects of antiepileptic drug therapy. Arch Neurol. 2001;58(9):1369-1374.

Watson KE, Abrolat ML, Malone LL, et al. Active serum vitamin D levels are inversely correlated with coronary calcification. Circulation. 1997;96(6):1755-1760.

Wilkinson RJ, Llewelyn M, Toossi Z, et al. Influence of vitamin D deficiency and vitamin D receptor polymorphisms on tuberculosis among Gujarati Asians in west London: a case-control study. Lancet. 2000;355(9204):618-621.

Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr. 2000;72(3):690-693.


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