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Vitamin B2

Vitamin B2 (Riboflavin) is a vitamin body uses for oxygen usage and the metabolism of amino acids, fatty acids, and carbohydrates, among other things.

Of these, of note is particularly the conversion of carbohydrates into sugar, which is used by the body to produce energy.

The vitamin may be also be used by the body for red blood cell formation, antibody production, cell respiration, and growth.

Riboflavin is best taken with B group vitamins and vitamin C.

However, B2 vitamin is needed to activate vitamin B6 (pyridoxine), which is why B6 vitamin intake should be controlled as well to enhance the efficiency of both.

Also, taking any one of the B complex vitamins can result in an imbalance of other important B vitamins. For this reason, it is generally important to keep a balance of the other B complex vitamins with any single B vitamin intake.

In terms of anti aging theories, B2 has an important part in the antioxidant theory of anti aging.

Riboflavin works as an antioxidant by neutralizing damaging particles in the body known as free radicals.

Unlike other B vitamins, riboflavin is not found in many foods, which is why the control of the intake of this vitamin is especially important in an anti aging regimen.

Vitamin B2 - Studies

Adelekan DA, Thurnham DI, Adekile AD. Reduced antioxidant capacity in paediatric patients with homozygous sickle cell disease. Eur J Clin Nutr. 1989;43(9):609-614.

Antoon AY, Donovan DK. Burn Injuries. In: Behrman RE, Kliegman RM, Jenson HB, eds. Nelson Textbook of Pediatrics. Philadelphia, Pa: W.B. Saunders Company; 2000:287-294.

Bell, IR, Edman JS, Morrow FD, et al. Brief communication. Vitamin B1, B2, and B6 augmentation of tricyclic antidepressant treatment in geriatric depression with cognitive dysfunction. J Am Coll Nutr. 1992;11(2):159-163.

Bomgaars L, Gunawardena S, Kelley SE, Ramu A. The inactivation of doxorubicin by long ultraviolet light. Cancer Chemother Pharmacol. 1997;40(6):506-512.

Cumming RG, Mitchell P, Smith W. Diet and cataract: the Blue Mountains Eye Study. Ophthalmology. 2000;107(3):450-456.

De-Souza DA, Greene LJ. Pharmacological nutrition after burn injury. J Nutr. 1998;128:797-803.

Dreizen S, McCredie KB, Keating MJ, Andersson BS. Nutritional deficiencies in patients receiving cancer chemotherapy. Postgrad Med. 1990;87(1):163-167, 170.

Fishman SM, Christian P, West KP. The role of vitamins in the prevention and control of anaemia. [Review]. Public Health Nutr. 2000;3(2):125-150.

Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academy Press; 1998.

Folkers K, Ellis J. Successful therapy with vitamin B6 and vitamin B2 of the carpal tunnel syndrome and need for determination of the RDAs for vitamins B6 and B2 for disease states. Ann NY Acad Sci. 1990;585:295-301.

Folkers K, Wolaniuk A, Vadhanavikit S. Enzymology of the response of the carpal tunnel syndrome to riboflavin and to combined riboflavin and pyridoxine. Proc Natl Acad Sci U S A. 1984;81(22):7076-7078.

Gartside PS, Glueck CJ. The important role of modifiable dietary and behavioral characteristics in the causation and prevention of coronary heart disease hospitalization and mortality: the prospective NHANES I follow-up study. J Am Coll Nutr. 1995;14(1):71-79.

Ghadirian P, Jain M, Ducic S, Shatenstein B, Morisset R. Nutritional factors in the aetiology of multiple sclerosis: a case-control study in Montreal, Canada. Int J Epidemiol. 1998;27(5):845-852.

Head KA. Natural therapies for ocular disorders, part two: cataracts and glaucoma. [Review]. Altern Med Rev. 2001;6(2):141-166.

Hill MJ. Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev. 1997;6(Suppl 1):S43-45.

Jacques PF, Chylack LT Jr, Hankinson SE, et al. Long-term nutrient intake and early age-related nuclear lens opacities. Arch Ophthalmol. 2001;119(7):1009-1019.

Kirschmann GJ, Kirschmann JD. Nutrition Almanac. 4th ed. New York: McGraw-Hill;1996:84-86.

Kuzniarz M, Mitchell P, Cumming RG, Flood VM. Use of vitamin supplements and cataract: the Blue Mountains Eye Study. Am J Ophthalmol. 2001;132(1):19-26.

LaVecchia C, Braga C, Negri E, et al. Intake of selected micronutrients and risk of colorectal cancer. Int J Cancer. 1997;73:525-530.

Lewis JA, Baer MT, Laufer MA. Urinary riboflavin and creatinine excretion in children treated with anticonvulsant drugs [letter]. Am J Dis Child. 1975;129:394.

Mauskop A. Alternative therapies in headache. Is there a role? [Review]. Med Clin North Am. 2001;85(4):1077-1084.

Meyer NA, Muller MJ, Herndon DN. Nutrient support of the healing wound. New Horizons. 1994;2(2):202-214.

Mulherin DM, Thurnham DI, Situnayake RD. Glutathione reductase activity, riboflavin status, and disease activity in rheumatoid arthritis. Ann Rheum Dis. 1996;55(11):837-840.

Nutrients and Nutritional Agents. In: Kastrup EK, Hines Burnham T, Short RM, et al, eds. Drug Facts and Comparisons. St. Louis, Mo: Facts and Comparisons; 2000:4-5.

Omray A. Evaluation of pharmacokinetic parameters of tetracylcine hydrochloride upon oral administration with vitamin C and vitamin B complex. Hindustan Antibiot Bull. 1981;23(VI):33-37.

Parks OW. Photodegredation of sulfa drugs by fluorescent light. J Assoc Off Anal Chem. 1985;68(6):1232-1234.

Pinto JT, Rivlin RS. Drugs that promote renal excretion of riboflavin. Drug Nutr Interact. 1987;5(3):143-151.

Ramu A, Mehta MM, Leaseburg T, Aleksic A. The enhancement of riboflavin-mediated photo-oxidation of doxorubicin by histidine and urocanic acid. Cancer Chemother Pharmacol. 2001;47(4):338-346.

Rock CL, Vasantharajan S. Vitamin status of eating disorder patients: Relationship to clinical indices and effect of treatment. Int J Eating Disord. 1995;18:257-262.

Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraneprophilaxis. A randomized controlled trial. Neurology. 1998;50:466–470.

Silberstein SD, Goadsby PJ, Lipton RB. Management of migraine: an algorithmic approach. [Review]. Neurology. 2000;55(9 Suppl 2):S46-52.

Takacs M, Vamos J, Papp Q, et al. In vitro interaction of selegiline, riboflavin and light. Sensitized photodegradation of drugs [in Hungarian] [Abstract]. Acta Pharm Hung. 1999;69(3):103-107.

Wolf E. Vitamin therapy helps fight CTS. Occup Health Saf. 1987;56(2):67.


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