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Topical Vitamin EThere are several types of E vitamins available, and research has suggested that the form d-Alpha-tocopheryl acetate has the ability to diffuse into skin cells where it is converted to d-alpha-tocopherol, the active form of E vitamin. In studies, Topical application of vitamin E and the combination of vitamins C and E have significantly protected the skin from UVB damage (sunburn cell formation) in a study in swine, for example. Similar results have been found in mice. Because most of the people on anti aging regimens have high protections against photoaging effects of UV irradiation, the most interesting parts of available research from this viewpoint have been on the restorative and rejuvenating effects of the topical compound. In one study of 20 women between 42 and 64 years of age, over one-half of the study subjects showed a significant decrease in wrinkle amplitude and roughness associated with photoaging on the eyelid treated daily with the vitamin E-containing cream for 4 weeks compared to the eyelid treated with placebo. In their conclusion, the researchers noted that the results suggested that topical use of vitamin E induced smoothing of fine lines and wrinkles in a sensitive area of the face. Topical Vitamin E - StudiesMayer, P., Pittermann, W. and Wallat, S. The Effects of Vitamin E on the Skin. Cosmetics and Toiletries 108:99-109, 1993. Lopez-Torres, M., Thiele, J.J., Shindo, Y., Han, D. and Packer, L. Topical Application of Alpha-Tocopherol Modulates the Antioxidant Network and Diminishes Ultraviolet-Induced Oxidative Damage in Murine Skin. Brit. J. Dermatol. 138:207-215, 1998. Potokar, M., Holtmann, W. and Werner-Busse, A. Effectiveness of Vitamin E Protection against UV Light – Comparative Testing of the Natural Tocopherols on the Skin of the Hairless Mouse. Fat Sci. Technol. 92:406-410, 1990. Trevithick, J., Xiong, H., Lee, S., Shum, D., Sanford, S., Karlik, S., Norley, C. and Dilworth, G. Topical Tocopherol Acetate Reduces Post-UVB, Sunburn-Associated Erythema, Edema and Skin Sensitivity in Hairless Mice. Arch. Biochem. Biophys. 296:575-582, 1992. Burke, K.E., Clive, J., Combs, G.F., Commisso, J., Keen, C.L. and Nakamura, R.M. Effects of Topical and Oral Vitamin E on Pigmentation and Skin Cancer Induced by Ultraviolet Irradiation in Skh:2 Hairless Mice. Nutr. Cancer 38: 87-97, 2000. Darr, D., Dunston, S., Faust, H. and Pinnell, S. Effectiveness of Antioxidants (Vitamin C and E) with and without Sunscreens as Topical Photoprotectants. Acta. Derm. Venerol. 76:264-268, 1996. Quevedo, W.C., Holstein, T.J., Dyckman, J., McDonald, C.J. and Isaacson, E.L. Inhibition of UVR-Induced Tanning and Immunosuppression by Topical Applications of Vitamins C and E to the Skin of Hairless Mice. Pigment Cell Res. 13:89-98, 2000. Record, I.R., Dreosti, I.E., Konstantinopoulos, M. and Buckley, R.A. The Influence of Topical and Systemic Vitamin E on Ultraviolet Light-Induced Skin Damage in Hairless Mice. Nutr. Cancer 16:219-225, 1991. Thiele, J.J., Traber, M.G., Podda, M., Tsang, K., Cross, C.E. and Packer, L. Ozone Depletes Tocopherols and Tocotrienols Topically Applied to Murine Skin. FEBS Letters 401:167-170, 1997. Gensler, H. and Magdaleno, M. Topical Vitamin E Inhibition of Immunosuppression and Tumorigenesis Induced by Ultraviolet Irradiation. Nutr. Cancer 15:97-106, 1991. Gensler, H.L., Aickin, M., Peng, Y.M. and Xu, M. Importance of the Form of Topical Vitamin E for Prevention of Photocarcinogenesis. Nutr. Cancer 26:183-191, 1996. The effects of topical vitamin E on the cosmetic appearance of scars. Baumann LS, Spencer J. Dermatol Surg. 1999 Apr;25(4):311-5. Trevithick JR, Xiong H, Lee S, et al. Topical tocopheryl acetate reduces post-UVB, sunburn-associated erythema, edema, and skin sensitivity in hairless mice. Arch Biochem Biophys. 1992; 296:575-582.
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