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TestosteroneIt has also been reported in research that the age-related decline of the hormone compound levels are faster in those who are overweight. In addition, as people get older, more testosterone is converted to estrogen than was the case during youth. In anti aging regimens, some use hormone replacement therapy to keep the levels of the hormone compound at youtful levels. These therapies, however, carry significant risks. The risks include increased risk of prostate cancer and other hormone sensitive cancers. Other risks include acne, deepening of voice, aggressiveness and menstrual changes in women. In addition, it has been suggested that too much testosterone many not be healthy for brain cells. However, there has been a comprehensive review of 72 studies on testosterone replacement therapy and it's health risk to men by Harvard University Medical School researchers. In a quote from the lead scientist of the study, Abraham Morgentaler, he stated "we reviewed decades of research and found no compelling evidence that testosterone replacement therapy increases the incidence of prostate cancer or cardiovascular disease". Also, in the retrospective review study, it was stated that studies of testosterone replacement therapy have not demonstrated an increased incidence of cardiovascular disease, myocardial infarction, stroke, or angina. In the hormone replacement therapies, the compound is delivered either through testosterone injections, testosterone cream, and testosterone gel. Testosterone - StudiesEffects of testosterone replacement therapy in old hypogonadal males: a preliminary study. Morley JE, Perry HM 3rd, Kaiser FE, Kraenzle D, Jensen J, Houston K, Mattammal M, Perry HM Jr. J Am Geriatr Soc. 1993 Feb;41(2):149-52. Testosterone replacement therapy improves mood in hypogonadal men--a clinical research center study. C Wang, G Alexander, N Berman, B Salehian, T Davidson, V McDonald, B Steiner, L Hull, C Callegari and RS Swerdloff. Journal of Clinical Endocrinology & Metabolism, 1996, Vol 81, 3578-3583. A. D. Seftel, R. J. Mack, A. R. Secrest, and T. M. Smith Restorative Increases in Serum Testosterone Levels Are Significantly Correlated to Improvements in Sexual Functioning. J Androl, November 1, 2004; 25(6): 963 - 972. K. T. Brill, A. L. Weltman, A. Gentili, J. T. Patrie, D. A. Fryburg, J. B. Hanks, R. J. Urban, and J. D. Veldhuis Single and Combined Effects of Growth Hormone and Testosterone Administration on Measures of Body Composition, Physical Performance, Mood, Sexual Function, Bone Turnover, and Muscle Gene Expression in Healthy Older Men. J. Clin. Endocrinol. Metab., December 1, 2002; 87(12): 5649 - 5657. L. Katznelson, M. W Robinson, C. L Coyle, H. Lee, and C. E Farrell. Effects of modest testosterone supplementation and exercise for 12 weeks on body composition and quality of life in elderly men. Eur. J. Endocrinol., December 1, 2006; 155(6): 867 - 875. M. G. Giannoulis, P. H. Sonksen, M. Umpleby, L. Breen, C. Pentecost, M. Whyte, C. V. McMillan, C. Bradley, and F. C. Martin. The Effects of Growth Hormone and/or Testosterone in Healthy Elderly Men: A Randomized Controlled Trial. J. Clin. Endocrinol. Metab., February 1, 2006; 91(2): 477 - 484. S. T. Page, J. K. Amory, F. D. Bowman, B. D. Anawalt, A. M. Matsumoto, W. J. Bremner, and J. L. Tenover. Exogenous Testosterone (T) Alone or with Finasteride Increases Physical Performance, Grip Strength, and Lean Body Mass in Older Men with Low Serum T. J. Clin. Endocrinol. Metab., March 1, 2005; 90(3): 1502 - 1510.
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