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Shark Liver OilBefore real scientific studies started in 1922 (when alkoxyglycerols where found) with the oil, Scandinavian fishermen used the oil externally to speed up wound healing and internally as a food supplement. The active compounds, alkoxyglycerols, have since been found in various other sources, including human breast milk. They are particularly rich in colostrum, the first milk produced only for a few days after birth. Other active compounds that have been studied and found in the liver oil from sharks include squalamine, and squalene. The liver oil from shark is also a rich source of vitamins A and D. Currently, no strong conclusion can be found for the effectiveness of the oil in anti aging, but the individual compounds have shown promise in several aspects of immune system enhancement and anti aging. Shark Liver Oil - StudiesBhargava P, Marshall JL, Dahut W, Rizvi N, Trocky N, Williams JI, et al. A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin Cancer Res. 2001;7(12):3912-3919. Brohult A, Brohult J, Brohult S, Joelsson I. Reduced mortality in cancer patients after administration of alkoxyglycerols. Acta Obstet Gynecol Scand. 1986;65(7):779-85. Das B, Yeger H, Baruchel H, Freedman MH, Koren G, Baruchel S. In vitro cytoprotective activity of squalene on a bone marrow versus neuroblastoma model of cisplatin-induced toxicity. Implications in cancer chemotherapy. Eur J Cancer. 2003;39(17):2556-2565. Hao D, Hammond LA, Eckhardt SG, Patnaik A, Takimoto CH, Schwartz GH, et al. A Phase I and pharmacokinetic study of squalamine, an aminosterol angiogenesis inhibitor. Clin Cancer Res. 2003;9(7):2465-2471. Herbst RS, Hammond LA, Carbone DP, Tran HT, Holroyd KJ, Desai A, et al. A phase I/IIA trial of continuous five-day infusion of squalamine lactate (MSI-1256F) plus carboplatin and paclitaxel in patients with advanced non-small cell lung cancer. Clin Cancer Res. 2003;9(11):4108-4115. Pugliese PT, Jordan K, Cederberg H, Brohult J. Some biological actions of alkylglycerols from shark liver oil. J Altern Complement Med. 1998;4:87-99. Sills AK Jr, Williams JI, Tyler BM, et al. Squalamine inhibits angiogenesis and solid tumor growth in vivo and perturbs embryonic vasculature. Cancer Res. 1998;58:2784-2792. Teicher BA, Williams JI, Takeuchi H, Ara G, Herbst RS, Buxton D. Potential of the aminosterol, squalamine in combination therapy in the rat 13,762 mammary carcinoma and the murine Lewis lung carcinoma. Anticancer Res. 1998;18:2567-2573.
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