SENS (Strategies for Engineered Negligible Senescence)

SENS (Strategies for Engineered Negligible Senescence) is a set of strategies and methods that aim to handle aging as an engineering process and to reverse aging instead of slowing it.

Traditional approach to aging, which is just a process of progressive changes in body composition, at the molecular and cellular level, is to slow down the accumulating damaging changes in this process.

For SENS, the engineering strategy is to repair the accumulating damage and indefinitely postpone the age at which it reaches pathogenic levels.

SENS acknowledges that there are 7 major contributors to the molecular and cellular level damage and proposes methods that can reverse the damage.

Below are the 7 major causes of damage caused by aging and SENS method for reversing this damage:

1. Cell loss, cell atrophy -> reversible with stem cells, growth factors, exercise
2. Nuclear [epi]mutations (only cancer matters) -> reversible with WILT (Whole-body Interdiction of Lengthening of Telomeres)
3. Mutant mitochondria -> reversible with Allotopic expression of 13 proteins
4. Death-resistant cells -> reversible with Cell ablation, reprogramming
5. Extracellular crosslinks -> reversible with AGE-breaking molecules/enzymes
6. Extracellular junk -> reversible with Phagocytosis; beta-breakers
7. Intracellular junk -> reversible with Transgenic microbial hydrolases

In addition there is a website available, at sens.org, with more information.

All in all, the authors of the SENS method predict that with adequate funding, these methods are a reality in animal studies in around ten years, with another ten years predicted before they reach humans.

SENS - Studies and Books

Ending Aging: The Rejuvenation Biotechnologies That Could Reverse Human Aging in Our Lifetime. Aubrey de Grey and Michael Rae. St. Martin's Press. September 4, 2007.


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