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Saw PalmettoThe beneficial effect of the herb extract on BPH seems to have been proven to some extend in recent clinical research. The mechanism behind this effect is reported to be that Saw Palmetto inhibits the conversion of testosterone to DHT, the compound thought to be responsible for the enlargement of the prostrate. However, in terms of anti aging remedies, the uses of the herb extract go beyond BPH. The mechanism of the herb extract of slowing down the breakdown of testosterone to Dihydrotestosterone is thought to be useful in prevention of premature male pattern baldness. Saw Palmetto - StudiesSerenoa repens (Permixon) inhibits the 5alpha-reductase activity of human prostate cancer cell lines without interfering with PSA expression. Int J Cancer. 2005 Mar 20;114(2):190-4. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia.J Altern Complement Med. 2002 Apr;8(2):143-52. Prager N, Bickett K, French N, Marcovici G. Clinical Research and Development Network, Aurora, CO, USA. Saw palmetto extract treatment modifies bax/bcl-2 index expression and caspase-3 activity in prostatic tissue from patients with benign prostatic hyperplasia. J Urol. 2005 Feb;173(2):507-10. Saw palmetto and benign prostatic hyperplasia. Am J Chin Med. 2004;32(3):331-8. Serenoa repens ( Permixon(R) - saw palmetto ) inhibits the 5alpha-reductase activity of human prostate cancer cell lines without interfering with PSA expression. Int J Cancer. 2004 Nov 12; Effect of permixon (saw palmetto extract) on human prostate cell growth: Lack of apoptotic action. Hill B, Kyprianou N. Division of Urology, University of Maryland School of Medicine, Baltimore, Maryland. Prostate. 2004 Sep 15;61(1):73-80. The role of a lipido-sterolic extract of Serenoa repens (saw palmetto) in the management of lower urinary tract symptoms associated with benign prostatic hyperplasia. BJU Int. 2004 Aug;94(3):338-44. Saw palmetto extract suppresses insulin-like growth factor-I signaling and induces stress-activated protein kinase/c-Jun N-terminal kinase phosphorylation in human prostate epithelial cells. Oregon Health and Science University, 3181 Sam Jackson Park Road, Portland, Endocrinology. 2004 Jul;145(7):3205-14. Epub 2004 Mar 19. Efficacy of pretreatment with Serenoa repens (saw palmetto) on bleeding associated with transurethral resection of prostateMinerva Urol Nefrol. 2004 Mar;56(1):73-8. Updated meta-analysis of clinical trials of Serenoa repens (saw palmetto) extract in the treatment of symptomatic benign prostatic hyperplasia. BJU Int. 2004 Apr;93(6):751-6. Multiple doses of saw palmetto (Serenoa repens) did not alter cytochrome P450 2D6 and 3A4 activity in normal volunteers. Clin Pharmacol Ther. 2003 Dec;74(6):536-42. Comparison of Saw Palmetto (extract and whole berry) and Cernitin on prostate growth in rats. Mol Cell Biochem. 2003 Aug;250(1-2):21-6. Long-term clinical and biologic effects of the lipidosterolic extract of Saw palmetto in patients with symptomatic benign prostatic hyperplasia. Adv Ther. 2002 Nov-Dec;19(6):297-306. The lipidosterolic extract of Serenoa repens (saw palmetto) in the treatment of benign prostatic hyperplasia: a comparison of two dosage regimens. Adv Ther. 2002 Nov-Dec;19(6):285-96. Randomized trial of a combination of natural products (cernitin, saw palmetto, B-sitosterol, vitamin E) on symptoms of benign prostatic hyperplasia. Preuss HG. Int Urol Nephrol 2001;33(2):217-25. Georgetown University Medical Center, Washington, DC 20007, USA.
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