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RutinIn research, the compound has been associated with several positive health effects, including that it seems to strengthen the capillaries. It may also help to reduce the cytotoxicity of oxidized LDL cholesterol and lower the risk of heart disease. In total, it has been suggested that the compound may have antioxidant, anti-inflammatory, anticarcinogenic, antithrombotic, cytoprotective and vasoprotective activities. It has been suggested that it may also help prevent the oxidation of vitamin C and thus make it safer and more useful in some conditions. Rutin - StudiesClement DL. Management of venous edema: insights from an international task force. Angiology. 2000; 51:13-17. Cruz T, Galvez J, Ocete MA, et al. Oral administration of rutoside can ameliorate inflammatory bowel disease in rats. Life Sci. 1998; 62:687-695. Deschner EE, Ruperto JF. Wong GY, Newmark HL. The effect of dietary quercetin and rutin on AOM-induced acute colonic epithelial abnormalities in mice fed a high-fat diet. Nutr Cancer. 1993; 20:199-204. Drewa G, Schachtschabel DO, Palgan K, et al. The influence of rutin on the weight, metastasis and melanin content of B16 melanotic melanoma in C57BL/6 mice. Neoplasma. 1998; 45:266-271. Galvez J, Cruz T, Crespo E, et al. Rutoside as mucosal protective in acetic acid-induced rat colitis. Planta Med. 1997; 63:409-414. Kostyuk VA, Potapovich AI. Antiradical and chelating effects in flavonoid protection against silica-induced cell injury. Arch Biochem Biophys. 1998; 355:43-48. Kostyuk VA, Potapovich AI, Speransky SD, Maslova GT. Protective effect of natural flavonoids on rat peritoneal macrophages injury caused by asbestos fiber. Free Rad Biol Med. 1996; 21:487-493. Olthof MR, Hollman PC, Vree TB, Katan MB. Bioavailabilities of quercetin-3-glucoside and quercetin-4'-glucoside do not differ in humans. J Nutr. 2000; 130:1200-1203. Park JB, Levine M. Intracellular accumulation of ascorbic acid is inhibited by flavonoids via blocking of dehydroascorbic acid and ascorbic acid uptakes in HL-60, U937 and Jurkat cells. J Nutr. 2000; 130:1297-1302. Perez Guerrero C, Martin MG, Marhuenda E. Prevention by rutin of gastric lesions induced by ethanol in rats: role of endogenous prostaglandins. Gen Pharmacol. 1994; 25:575-580. Rueff J, Gaspar J, Laires A. Structural requirements for mutagenicity of flavonoids upon nitrosation. A structure-activity study. Mutagenesis. 1995; 10:325-328. Schmitt A, Savayre R, Delchambre J, Negre-Salvayre A. Prevention by alpha-tocopherol and rutin of glutathione and ATP depletion induced by oxidized LDL in cultured endothelial cells. Br J Pharmacol. 1995; 116:1985-1990. Webster RP, Gawde MD, Bhattacharya RK, Protective effect of rutin, a flavonol glycoside, on the carcinogen-induced DNA damage and repair enzymes in rats. Cancer Lett. 1996; 109:185-191.
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