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Retin AIn fact, topical tretinoin is one of very few substances whose anti aging effects on the skin have been documented in many well-designed studies of various duration. In studies, the compound has been found to reduce fine wrinkles and skin roughness, increase epidermal thickness, stimulate deposition of collagen, accelerate skin-cell turnover, stimulate blood-vessel growth, and boost production of elastin fibers. Even though the compounds anti aging effect on the skin can be seen relatively quickly, according to the studies, improvement on tretinoin may continue for up to a year of continued use. There are many significant side effects to the use of Retin A, including sensitivity to sun, which requires increased levels of very high sun protection with sun screens. Also, an unusual darkening of the skin or lack of color of the skin may occur temporarily with repeated application as well as burning sensation to the skin, dry skin, itching, peeling, redness, and stinging. Retin A - StudiesWeiss JS, Ellis CN, Goldfarb MT, et al. Tretinoin therapy: practical aspects of evaluation and treatment. J Int Med Res 1990;18(Suppl 3):41-8C. Olsen EA, Katz HI, Levine N, et al. Tretinoin emollient cream: a new therapy for photodamaged skin. J Am Acad Dermatol 1992;26(2 Pt 1):215-24. Gilchrest BA. Retinoids and photodamage. Br J Dermatol 1992;127(Suppl 41):14-20. Kligman AM. Topical retinoic acid (tretinoin) for photoaging: conceptions and misperceptions. Cutis 1996;57(3):142-4. Robinson TA, Kligman AM. Treatment of solar keratoses of the extremities with retinoic acid and 5-fluorouracil. Br J Dermatol 1975;92(6):703-6.
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