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Red Clover ExtractThe active substances that are responsible for this effectiveness are isoflavones and anticoagulant chemicals called coumarins. However, despite the positive results from several studies on menopausal women and the extract, it is still used mainly in alternative medicine. This is mainly because it is still unclear just how the extract functions in the treatment of menopausal symptoms. In alternative medicine, the herb is sometimes found combined with black cohosh and other herbs in many herbal formulas for menopause. Red Clover Extract - StudiesThe effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: A randomized, double-blind, placebo-controlled study. Gynecology Endocrinol. 2005 Nov;21(5):257-264. Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense). J Agric Food Chem. 2005 Aug 10;53(16):6246-53. Overk CR, Yao P. Phytoestrogens derived from red clover: An alternative to estrogen replacement therapy? J Steroid Biochem Mol Biol. 2005 Apr;94(5):499-518. Modest protective effects of isoflavones from a red clover -derived dietary supplement on cardiovascular disease risk factors in perimenopausal women. J Nutr. 2004 Jul;134(7):1759-64. Effect of red clover isoflavones on cox-2 activity in murine and human monocyte/macrophage cells. Nutr Cancer. 2004;49(1):89-93. Red clover isoflavones in practice: a clinician's view. J Br Menopause Soc. 2004 Mar;10 Suppl 1:7-12. The effects of dietary supplementation with isoflavones from red clover on cognitive function in postmenopausal women. Climacteric. 2004 Mar;7(1):70-7. The effects of red clover isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr. 2004 Feb;79(2):326-33. Red clover-derived isoflavones and mammographic breast density: a double-blind, randomized, placebo-controlled trial. Atkinson C, Warren RM, Sala E et al. Breast Cancer Res. 2004;6:R170-R179.
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