 |
QuercetinThe compound has received more attention that most of the anti aging flavonoids, particularly due to the fact that the compound has been found to be the most active of the flavonoids in studies, and many medicinal plants owe much of their activity to their high quercetin content. Of the anti aging features of the compound, one is significant anti-inflammatory activity due to direct inhibition of several initial processes of inflammation. As an antioxidant, it has shown potency as well as interacting with other antioxidants and has shown vitamin C sparing action, which also promotes the potency of other antioxidants. From natural sources, quercetin can be found from apples, black & green tea, onions, red wine, red grapes, citrus fruits, broccoli & other leafy green vegetables, cherries, and a number of berries including raspberry, bog whortleberry, lingonberry, cranberry, chokeberry, sweet rowan, rowanberry, sea buckthorn berry, crowberry, and the fruit of the prickly pear cactus. Quercetin - StudiesAlarcon de la Lastra C. Martin MJ, Motilve V. Antiulcer and gastroprotective effects of quercetin: a gross and histologic study. Pharmacol. 1994; 48:56-62. Boulton DW, Walle UK, Walle T. Extensive binding of the bioflavonoid quercetin to human plasma proteins. J Pharm Pharmacol. 1998; 50:243-249. Conquer JA, Maiani G, Azzini E, et al. Supplementation with quercetin markedly increases plasma quercetin concentration without effect on selected risk factors for heart disease in healthy subjects. J Nutr. 1998; 128:593-597. Costantino L, Rastelli G, Gamberini MC, et al. 1-Benzopyran-4-one antioxidants as aldose reductase inhibitors. J Med Chem. 1999; 42:1881-1893. de Vries JH, Jenssen PL, Hollman PC, et al. Consumption of quercetin and kaempferol in free-living subjects eating a variety of diets. Cancer Lett. 1997. 114:141-144. Ferry DR, Smith A, Malkhandi J, et al. Phase I clinical trial of the flavonoid quercetine: phonmacokinetics and evidence for tyrosine kinase inhibition. Clin Cancer Res. 1996; 2:659-668. Hilliard JJ, Krause HM, Bernstein JI, et al. A comparison of active site binding of 4-quinolones and novel flavone gyrase inhibitors to DNA gyrase. Adv Exp Med Biol. 1995; 390:59-69. Hollman PC, Bijsman MN, van Gameren Y, et al. The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man. Free Rad Res. 1999; 31:569-573. Hollman PC, de Vries JH, van Leeuwen SD, et al. Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers. Am J Clin Nutr. 1995; 62:1276-1282. Hollman PCH, van Trijp JMP, Mengelers MJB, et al. Bioavailability of the dietary antioxidant flavonol quercetin in man. Cancer Lett. 1997; 114:139-140. Hollman PCH, Gaag MVD, Mengelers MJB, et al. Absorpotion and disposition kinetics of the dietary antioxidant quercetin in man. Free Red Biol Med. 1996; 21:703-707. Ito N, Hagiwara A, Tamano S, et al. Lack of carcinogencity of quercetin in F344/DuCrj rats. Jpn J Cancer Res. 1989; 80:317-325. Martin MJ, La-Casa C, Alarcon-de-la-Lastra C, et al. Anti-oxidant mechanisms involved in gastroprotective effects of quercetin. Z Naturforsch[C]. 1998; 53:82-88. Middleton Jr E, Anne S. Quercetin inhibits lipopolysaccharide-induced expression of endothelial cell intracellular adhesion molecule-1. Int Arch Allergy Immunol. 1995; 107:435-436. Sato M, Miyazaki T, Kambe F, et al. Quercetin, a bioflavonoid, inhibits the induction of interleukin 8 and monocyte chemoattractant protein-1 expression by tumor necrosis factor-alpha in cultured human synovial cells. J Rheumatol. 1997; 24:1680-1684. Shoskes DA. Effect of the bioflavonoids quercetin and curcumin on ischemic renal injury: a new class of renoprotective agents. Transplantation. 1998; 66:147-152. Shoskes DA, Zeitlin SI, Shahed A, Rajfer J. Quercetin in men with category III chronic prostatitis: a preliminary prospective double-blind, placebo-controlled trial. Urology. 1999; 54:960-963. Stavric B. Quercetin in our diet: from potent mutagen to probable anticarcinogen. Clin Biochem. 1994; 27:245-248. Varma SD, Kinoshita JH. Inhibition of lens aldose reductase by flavonoids. Their possible role in the prevention of diabetic cataracts. Biochem Pharmacol. 1976; 25:2505-2513.
|