Pycnogenol
Pycnogenol is extracted from Pinus maritima and contains flavonoids, catechins, phenolic acids, and especially proanthocyanidins.
These compounds have been each associated with anti aging, especially proanthocyanidins, which provide anti oxidant protection to the body against free radicals that contribute to the aging process.
These active compounds (particularly the high concentration of proanthocyanidins) are believed to contribute the main effectiveness of the health benefits found for the extract in studies.
The extract has been evaluated for prevention and treatment of diabetes, diabetic retinopathy, and diabetic blood vessel health, asthma, dysmenorrhea (menstrual pain), reduction of thrombophlebitis during long flights, and hypertension.
Pycnogenol - Studies
Improvement of diabetic microangiopathy with pycnogenol: A prospective, controlled study. Angiology. 2006 Aug-Sep;57(4):431-6.
Pycnogenol induces differentiation and apoptosis in human promyeloid leukemia HL-60 cells. Leuk Res. 2005 Jun;29(6):685-92. Epub 2005 Jan 19.
Pycnogenol stimulates lipolysis in 3t3-L1 cells via stimulation of beta-receptor mediated activity. Phytother Res. 2004 Dec;18(12):1029-30.
Therapeutic efficacy of pycnogenol in experimental inflammatory bowel diseases. Phytother Res. 2004 Dec;18(12):1027-8.
Pycnogenol as an adjunct in the management of childhood asthma.
J Asthma. 2004;41(8):825-32. Lau BH, Riesen SK, Truong KP, Lau EW, Rohdewald P, Barreta RA.
Analgesic efficacy of French maritime pine bark extract in dysmenorrhea: an open clinical trial. J Reprod Med. 2004 Oct;49(10):828-32.
Prevention of venous thrombosis and thrombophlebitis in long-haul flights with pycnogenol. Clin Appl Thromb Hemost. 2004 Oct;10(4):373-7.
Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci. 2004 Oct 8;75(21):2505-13.
Pycnogenol, French maritime pine bark extract, improves endothelial function of hypertensive patients. Life Sci. 2004 Jan 2;74(7):855-62.
Treatment of erectile dysfunction with pycnogenol and L-arginine. J Sex Marital Ther. 2003 May-Jun;29(3):207-13.
Pycnogenol prevents haemolytic injury in G6PD deficient human erythrocytes. Phytother Res. 2003 Jun;17(6):671-4.
Pycnogenol inhibits the release of histamine from mast cells. Phytother Res. 2003 Jan;17(1):66-9.
Pycnogenol for diabetic retinopathy. A review. Int Ophthalmol. 2001;24(3):161-71.
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