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ProanthocyanidinsProanthocyanidins are polyphenols that have been reputed with a wider range of antioxidant capabilities than either vitamin C or E. There is increasing evidence from research that polyphenols, flavanols, and proanthocyanidins offer significant anti aging protection to the cardiovascular system. Also, the compound has shown promise in the prevention of diseases such as atherosclerosis, gastric ulcer, large bowel cancer, cataracts and diabetes. One of the best sources for the compound is grape seed extract, which is used as the base for many dietary supplements that provide the compounds. Grape seed extract has been used in some human trials. In one, it was shown to have preventive effects on the increase in lipid peroxides in human plasma after exercise and on muscle fatigue after training. Proanthocyanidins - StudiesProanthocyanidins in health care: current and new trends. Curr Med Chem. 2004 May;11(10):1345-59. Ingestion of proanthocyanidins derived from cacao inhibits diabetes-induced cataract formation in rats. Exp Biol Med (Maywood). 2004 Jan;229(1):33-9. Antioxidant properties of proanthocyanidins of Uncaria tomentosa bark decoction: a mechanism for anti-inflammatory activity. Phytochemistry. 2005 Jan;66(1):89-98.
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