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Phosphatidyl SerineMost notably, the compound is found in the cell membrane of neurons, comprising about 7 to 10 percent of its lipid content. In the past (to mid 90s), the compound was derived from cow brains for supplement use, but due to the potential that there may be viruses from the cow in those extracts, the current supplements that use the compound are derived from soy. Much of the past research that showed positive effects on the human brain functioning of the compound was done on the cow brain extract, which included other components beside phosphatidylserine. Many researchers agree that the scientific community cannot use the previous positive research findings on the cow brain derived compound to assess the health effects of the soy-derived phosphatidylserine. The current research that is done on the soy-derived compound has given somewhat mixed results, with some suggesting that the compound has a positive results on brain function, and some not supporting that claim. Phosphatidyl Serine - StudiesEffects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress. Stress. 2004 Jun;7(2):119-26. Safety of soy-derived phosphatidylserine in elderly people. Nutr Neurosci. 2002 Oct;5(5):337-43. The influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor. Benton D. Nutr Neurosci 2001;4(3):169-78. The influence of soy-derived phosphatidylserine on cognition in age-associated memory impairment. Jorisse BL. Nutr Neurosci 2001;4(2):121-34 An open trial of plant-source derived phosphatidylserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci. 2000;37(4):302-7.
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