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PepsinHowever, digestion of proteins may be initiated by the compound in the stomach, but most of protein digestion is due to the pancreatic proteases secreted in the small intestine. As a group, digestive enzymes are essential to the body's absorption and full use of food. With aging, the body's capacity to make enzymes diminishes. Also, modern lifestyle foods that people eat contain mostly no food enzymes (present in the foods originally before preparation) to assist in the digestion of the foods. If there is there is problems in the body ability to get enough enzymes for food digestion, some suggest that there are several potential harmful effects that can result from the left over waste of incomplete digestion. However, if there is too much pepsin and/or too acidic environment in the stomach, some suggest that gastroesophageal reflux disease (GERD), or commonly, heartburn, causes more damage to the esophagus, which is affected by the condition. Pepsin - StudiesA Study of Gastric Pepsin in Various Disease. Clinton R. Mullins and Charles A. Flood. J Clin Invest. 1935 November; 14(6): 793–797. Studies of Gastric Pepsin. II. Secretion of Pepsin in Cases of Duodenal Ulcer and Pseudo-Ulcer. Vanzant, Frances R.;Osterberg, Arnold E.;Alvarez, Walter C.; Rivers, Andrew B. J Clin Invest. 1933 May;12(3):557–565. Polland, W Scott.; Bloomfield, Arthur L. The Diagnostic Value of Determinations of Pepsin in Gastric Juice. J Clin Invest. 1930 Aug;9(1):107–113.
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