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Pau D'Arco ExtractEver since the Inca Empire times, this herb has been used widely in alternative medicine in the areas where it is found, Brazil and Northern Argentina. The active ingredient in the extract is believed to be lapachol, which has been under ongoing research. Overall, the extract has shown significant anti oxidant properties, similar to Vitamin E. Most of the chemical research on pau d'arco has been done on the wood and not the bark, although it is in fact the inner bark that has been used traditionally for medicinal purposes. In addition, there are a variety of the tree species that have been tested for anti-infectious and anti-cancer properties, which causes further confusion when translating the results. Pau D'Arco Extract - StudiesAntioxidant activity and characterization of volatile constituents of Taheebo (Tabebuia impetiginosa Martius ex DC) - Pau D'arco. J Agric Food Chem 2003 Jan 1;51(1):295-300. Constituents from the bark of Tabebuia impetiginosa (Pau D'arco). Phytochemistry. 2004 Jul;65(13):2003-11. Anesini C, Perez C. Screening of plants used in Argentine folk medicine for antimicrobial activity. J Ethnopharmacol. 1993;39:119–128. Colman de Saizarbitoria T, Anderson JE, Alfonso D, McLaughlin JL.Bioactive furonaphtoquinones from Tabebuia barbata (Bignoniaceae). Acta Cient Venez. 1997;48(1):42-46. Dinnen RD, Ebisuzaki K. The search for novel anticancer agents: a differentiation-based assay and analysis of a folklore product. Anticancer Res. 1997;(2A):1027–1033. Kinghorn AD, Balandrin MA, eds. American Chemical Symposium Series. Human Medicinal Agents from Plants. Washington, DC: American Chemical Society; 1992:16–17. Miranda FG, Vilar JC, Alves IA, Cavalcanti SC, Antoniolli AR. Antinociceptive and antiedematogenic properties and acute toxicity of Tabebuia avellanedae Lor. ex Griseb. inner bark aqueous extract. BMC Pharmacol. 2001;1(1):6. Muller K, Sellmer A, Wiegrebe W. Potential antipsoriatic agents: lapacho compounds as potent inhibitors of HaCaT cell growth. J Nat Prod. 1999;62(8):1134-1136. Pinto CN, Dantas AP, De Moura KC, et al. Chemical reactivity studies with naphthoquinones from Tabebuia with anti-trypanosomal efficacy. Arzneimittelforschung. 2000;50(12):1120-1128. Pizzorno JE, Murray MT. Textbook of Natural Medicine. New York: Churchill Livingstone; 1999:967-974. Portillo A, Vila R, Freixa B, Adzet T, Canigueral S. Antifungal activity of Paraguayan plants used in traditional medicine. J Ethnopharmacol .2001;76(1):93-98. Robbers JE, Tyler VE. Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press; 1999:246-247. Ueda S, Umemura T, Dohguchi K, et al. Production of anti-tumour-promoting furanonaphthoquinones in Tabebuia avellanedae cell cultures. Phytochemistry. 1994;36:323–325.
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