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PapainEnzymes, as a group, accelerate reactions within body cells. In the body, the pancreas usually produce digestive enzymes that break down foods into nutrients that the body can use for energy and other functions. In studies of cancer patients, oral enzyme supplements containing papain have shown promise in helping to relieve treatment side effects such as mouth sores and difficulty swallowing. Also, interestingly from anti aging viewpoint, chemicals in papain have also shown potential for increasing the function of the immune system and they may also promote the release of natural chemicals that attack tumor cells. Papain may lessen overall inflammation, as well. Furthermore, there is some evidence that shows that the compound may help to prevent complications of diabetes, possibly by lessening protein deposits in the kidneys. However, much more study is needed on the compound. Papain - StudiesAdebiyi A, Adaikan PG, Prasad RN. Papaya (Carica papaya) consumption is unsafe in pregnancy: fact or fable? Scientific evaluation of a common belief in some parts of Asia using a rat model. British Journal of Nutrition. 2002;88(2):199-203. Australian Government Department of Health and Ageing. The biology and ecology of papaya (paw paw), Carica papaya L., in Australia. April 2003. Available at: http://www.health.gov.au/ogtr/rtf/ir/papaya.rtf. Accessed August 11, 2003. Bahl A, Chander S, Julka PK, et al. Micronuclei evaluation of reduction in neoadjuvant chemotherapy related acute toxicity in locally advanced lung cancer: an Indian experience. Journal of the Association of Physicians of India. 2006;54:191-195. Beuth J, Ost B, Pakdaman A, et al. Impact of complementary oral enzyme application on the postoperative treatment results of breast cancer patients--results of an epidemiological multicentre [sic] retrolective cohort study. Cancer Chemotherapy and Pharmacology. 2001;47 Suppl:S45-S54. Bienen H, Raus I. Therapeutic comparison of throat lozenges; (author's translation). [Article in German]. MMW Muenchener Medizinische Wochenschrift. 1981;123(18):745-747. Billigmann P. Enzyme therapy--an alternative in treatment of herpes zoster. A controlled study of 192 patients. [Article in German] Fortschritte Der Medizin. 1995;113(4):43-48. Chakraborty P, Ghosh D, Chowdhury I, et al. Aerobiological and immunochemical studies on Carica papaya L. pollen: an aeroallergen from India. Allergy. 2005;60(7):920-926. Chaudhry AS. Comparing two commercial enzymes to estimate in vitro proteolysis of purified or semi-purified proteins. Journal of Animal Physiology and Animal Nutrition (Berlin). 2005 Dec;89(11-12):403-12. Dale PS, Tamhankar CP, George D, Daftary GV. Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects. Cancer Chemotherapy and Pharmacology. 2001;47(Suppl):S29-S34. Dawkins G, Hewitt H, Wint Y, Obiefuna PC, Wint B. Antibacterial effects of Carica papaya fruit on common wound organisms. West Indian Medical Journal. 2003;52(4):290-292. Diez-Gomez ML, Quirce S, Aragoneses E, Cuevas M. Asthma caused by Ficus benjamina latex: evidence of cross-reactivity with fig fruit and papain. Annals of Allergy, Asthma and Immunology, 1998;80(1):24-30. Dominguez de Maria P, Sinisterra JV, Tsai SW, Alcantara AR. Carica papaya lipase (CPL): an emerging and versatile biocatalyst. Biotechnology Advances. 2006;24(5):493-499. Duke JA. Carica papaya L. Handbook of Energy Crops. 1983. Unpublished. Available at: http://www.hort.purdue.edu/newcrop/duke_energy/Carica_papaya.html. Accessed August 11, 2003. Food and Drug Administration. FDA grants orphan drug status to wobe-mugos for multiple myeloma. [press release] August 10, 2000. Giuliano AR, Siegel EM, Roe DJ, et al; for the Ludwig-McGill HPV Natural History Study. Dietary intake and risk of persistent human papillomavirus (HPV) infection: the Ludwig-McGill HPV Natural History Study. Journal of Infectious Diseases. 2003;188(10):1508-1516. Gujral MS, Patnaik PM, Kaul R, et al. Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers. Cancer Chemotherapy and Pharmacology. 2001;47 Suppl:S23-S28. HealthNotes, Inc. Digestive enzymes. 2002. Available at: http://www.mycustompak.com/healthNotes/Supp/Enzymes.htm Accessed August 15, 2003. Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. American Journal of Health System Pharmacy. 2000;57(13):1221-1230. Hemmer W, Focke M, Gotz M, Jarisch R. Sensitization to Ficus benjamina: relationship to natural rubber latex allergy and identification of foods implicated in the Ficus-fruit syndrome. Clinical and Experimental Allergy. 2004;34(8):1251-1258. Hewitt H, Whittle S, Lopez S, Bailey E, Weaver S. Topical use of papaya in chronic skin ulcer therapy in Jamaica. West Indian Medical Journal. 2000;49(1):32-33. Jellin JM, Gregory P, Batz F, Hitchens K, et al, eds. Pharmacist's Letter/Prescriber's Letter. Natural Medicines Comprehensive Database, 3rd Edition. Stockton CA: Therapeutic Research Facility, 2000. Kamaruzzaman M, Chowdhury SD, Podder CK, Pramanik MA. Dried papaya skin as a dietary ingredient for broiler chickens. British Poultry Science. 2005;46(3):390-393. Leipner J, Iten F, Saller R. Therapy with proteolytic enzymes in rheumatic disorders. BioDrugs. 2001;15(12):779-789. Leipner J, Saller R. Systemic enzyme therapy in oncology: effect and mode of action. Drugs. 2000;59(4):7697-80. Lubec G, Forster O, Coradello H, Maxa E, Pollak A. Proteolytic degradation of the glomerular basement membrane and immunochemical characterization of split products. Renal Physiology. 1980;3(1-6):126-132. Lubec G, Pollak A. Reduced susceptibility of nonenzymatically glucosylated glomerular basement membrane to proteases: is thickening of diabetic glomerular basement membranes due to reduced proteolytic degradation? Renal Physiology. 1980;3(1-6):4-8. Mahattanatawee K, Manthey JA, Luzio G, Talcott ST, Goodner K, Baldwin EA. Total antioxidant activity and fiber content of select Florida-grown tropical fruits. Journal of Agricultural and Food Chemistry. 2006 Sep 20;54(19):7355-7363. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Annals of Allergy. 1985;55(4):541-543. Martin T, Uhder K, Kurek R, et al. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial. Radiotherapy in Oncology. 2002;65(1):17-22. Mikhalchik EV, Ivanova AV, Anurov MV, et al. Wound-Healing Effect of Papaya-Based Preparation in Experimental Thermal Trauma. Bulletin of Experimental Biology in Medicine. 2004;137(6):560-562. Oderinde O, Noronha C, Oremosu A, Kusemiju T, Okanlawon OA. Abortifacient properties of aqueous extract of Carica papaya (Linn) seeds on female Sprague-Dawley rats. Nigerian Postgraduate Medical Journal. 2002;9(2):95-98. Pieper B, Caliri MH. Nontraditional wound care: A review of the evidence for the use of sugar, papaya/papain, and fatty acids. Journal of Wound, Ostomy and Continence Nursing. 2003;30(4):175-183. Popiela T, Kulig J, Hanisch J, Bock PR. Influence of a complementary treatment with oral enzymes on patients with colorectal cancers--an epidemiological retrolective cohort study. Cancer Chemotherapy and Pharmacology. 2001;47 Suppl:S55-S63. Raus I. Clinical studies on Frubienzyme in a controlled double-blind trial. [Article in German] Fortschritte Der Medizin.1976;94(28):1579-1582. Roep BO, van den Engel NK, van Halteren AG, Duinkerken G, Martin S. Modulation of autoimmunity to beta-cell antigens by proteases. Diabetologia. 2002;45(5):686-692. Runnie I, Salleh MN, Mohamed S, Head RJ, Abeywardena MY. Vasorelaxation induced by common edible tropical plant extracts in isolated rat aorta and mesenteric vascular bed. Journal of Ethnopharmacology. 2004;92(2-3):311-316. Sakalova A, Bock PR, Dedik L, et al. Retrolective cohort study of an additive therapy with an oral enzyme preparation in patients with multiple myeloma. Cancer Chemotherapy and Pharmacology. 2001;47 Suppl:S38-S44. Savickiene N, Dagilyte A, Lukosius A, Zitkevicius V. Importance of biologically active components and plants in the prevention of complications of diabetes mellitus. [Article in Lithuanian] Medicina (Kaunas). 2002;38(10):970-975. Starley IF, Mohammed P, Schneider G, Bickler SW. The treatment of paediatric burns using topical papaya. Burns. 1999;25(7):636-639. Steffen C, Menzel J. In vivo degradation of immune complexes in the kidney by orally administered enzymes. [Article in German] Wiener Klinische Wochenschrift. 1987;99(15):525-531. Stepek G, Lowe AE, Buttle DJ, Duce IR, Behnke JM. In vitro and in vivo anthelmintic efficacy of plant cysteine proteinases against the rodent gastrointestinal nematode, Trichuris muris. Parasitology. 2006;132(Pt 5):681-689. Tavares FX, Deaton DN, Miller AB, Miller LR, Wright LL, Zhou HQ. Potent and selective ketoamide-based inhibitors of cysteine protease, cathepsin k. Journal of Medicinal Chemistry. 2004;47(21):5049-5056. van Kampen V, Merget R, Bruning T. Occupational allergies to papain. [Article in German] Pneumologie. 2005;59(6):405-410. . Wald M, Zavadova E, Pouckova P, Zadinova M, Boubelik M. Polyenzyme preparation Wobe-Mugos inhibits growth of solid tumors and development of experimental metastases in mice. Life Sciences. 1998;63(8):PL43-48. Zavadova E, Desser L, Mohr T. Stimulation of reactive oxygen species production and cytotoxicity in human neutrophils in vitro and after oral administration of a polyenzyme preparation. Cancer Biotherapy 1995;10(2):147-152.
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