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MSMIn this regard, many supplements contain the compound together with Chondroitin and Glucosamine, which have been found in research to have similar and complimentary effects to MSM. The compound is an important component of proteins found throughout the body, including proteins in hair, nails, skin and tendons. Studies have shown that in vertebrates, the concentration of MSM decreases with age. This is interesting, as some research suggests that there is a minimum concentration of MSM that must be maintained in the body to preserve normal function and structure. In terms of anti aging, it is also interesting that in research done at Ohio State University College of Medicine oral MSM showed promise in protection of rats against the onset of breast cancer. MSM - StudiesMcCabe, D., Eugene W., et al., Polar solvents in the chemoprevention of dimethlenzanthracene-induced rat mammary cancer, Archives of Surgery, 1986, Vol. 121:1455-59. O'Dwyer, P.J. et al., Use of polar solvents in chemoprevention of 1,2-dimethylhydrazine-induced colon cancer, Cancer, Vol. 62:944 (1988). Efficacy of methylsulfonylmethane ( MSM ) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage. 2005 Nov 22; Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF. A multicentered, open-label trial on the safety and efficacy of methylsulfonylmethane (MSM) in the treatment of seasonal allergic rhinitis. Barrager E,. J Altern Complement Med. 2002 Apr;8(2):167-73. Toxicity of methylsulfonylmethane (MSM) in rats. Food Chem Toxicol. 2002 Oct;40(10):1459-62. Methylsulfonylmethane observed by in vivo proton magnetic resonance spectroscopy in a 5-year-old child with developmental disorder: effects of dietary supplementation. J Comput Assist Tomogr. 2002 Sep-Oct;26(5):818-20. Accumulation of methylsulfonylmethane in the human brain: identification by multinuclear magnetic resonance spectroscopy. Lin A, Nguy CH, Shic F, Ross BD. Toxicol Lett 2001 Sep 15;123(2-3):169-77. Williams, K.I.H., et al., Dimethyl sulfone: Isolation from human urine, Archives of Biochemistry and Biophysics, Vol. 113: 215-2, (1966).
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