 |
MelatoninAvailable studies suggest that the importance of maintaining melatonin at youthful levels will help protect against age-related degenerative diseases. The hormone is secreted by the pineal gland, a pea-size structure at the center of the brain, as our eyes register the fall of darkness. This helps our bodies regulate our sleep-wake cycles. The most common use of the hormone, so far, has been to hasten sleep and ease jet lag, without the hazards or side effects of prescription sleeping pills. 60 million Americans have sleep disorders, and these can significantly contribute to stress levels people feel, which is one of the aging accelerating factors. However, the hormone's other uses, beside sleep disorders, are under much research and the hormone has been reported to make people feel better and strengthen the immune system so far. Melatonin - StudiesBonn, D., Melatonin's Multifarious Marvels: Miracle or Myth? Science and Medicine, 1996. 347 (January 20): p. 184 Lewin, D.I., Special Section: Hormones, Researchers Cycle Down the Path to Elucidating Melatonin's Rhythms. The Journal of NIH Research, 1996. 8 (April): p. 45-49 Reppert, S.M., David R. Weaver, Melatonin Madness. Cell, 1995. (December 29): p. 1059-1062. Turek, F.W., Melatonin hype hard to swallow. Nature, 1996. 379 (January 25): p. 295-296. Nowak, R., I.C. McMillen, J. Redman, R.V. Short, The Correlation Between Serum and Salivary Melatonin Concentrations and Urinary 6-Hydroxymelatonin Sulphate Excretion Rates: Two Non-Invasive Techniques for Monitoring Human Circadian Rhythmicity. Clinical Endocrinology, 1987. 27: p. 445-452 Plenzer, S.C., P.J.M., B.L. Myers, K.P. Wright, Jr., P. Badia, G. Kellerman, Reliability of Salivary Melatonin. Sleep Research, 1995. 24: p. 535. Sack, R.L., Alfred J. Lewy, Danielle L. Erb, William M. Vollmer, Clifford Singer, Human Melatonin Prodution Decreases With Age. Journal of Pineal Research, 1986. 3: p. 379-388. Dollins, A.B., Irina V. Zhdanova, J. Wurtman, Harry J. Lynch, Mei H. Deng, Effect of Inducting Nocturnal Serum Melatonin Concentrations in Daytime Sleep, Mood, Body Temperature, and Performance. Physiology, 1994. 91 (March): p. 1824-1828. Gonzalez R., A.S., J. A. Ferguson, C. Balmer, C. Daniel, A. Cohn, W.A. Robinson, Melatonin Therapy of Advanced Human Malignant Melanoma. Melanoma Research, 1991. 1: p. 237-243. Neville S., J. Arendt, C. Ionnides, A Study of Mutagenicity of Melatonin and 6-Hydroxymelatonin. Journal of Pineal Research, 1989. 6: p. 73-76. Papayasiliou Paul S., G.C.C., Simone E. Duby, Andreas J. Steck, Margaret Bell, William H. Lawrence, Melatonin and Parkinsonism. JAMA, 1972. 221, No 1 (July 3): p. 88. Sugden D., Psychopharmacological Effects of Melatonin in Mouse and Rat. Journal of Pharmacology and Experimental Therapeutics, 1983. 227, No 3: p. 587-591. Wright J., M.A., C. Franey, J. English, J. Arendt, The Effects of Exogenous Melatonin On Endocrine Function in Man. Clinical Endocrinology, 1986. 24: p. 375-382. Arendt J., M. Aldous, J. English, V. Marks, J.H. Arendt, Some Effects of Jet Lag and Their Alleviation by Melatonin. Ergonomics, 1987. 20, No 9: p. 1379-1393. Attenburrow M., Sharpley A.L., Cowen P.J., The Acute Effects of Low Dose Melatonin On Sleep. British Association for Psychopharmacology, 1995. Dawson D., Encel N., Melatonin and Sleep in Humans. Journal of Pineal Research, 1993. 15: p. 1-15. Haimov I., Peretz Lavie, Moshe Laudon, Paula Herer, C. Vigder, Nava Zisapel, Melatonin Replacement Therapy of Elderly Insomniacs. Sleep, 1995. 18(7): p. 598-603. Zhdanova I.V., PhD., R.J. Wurtman, MD, H.J. Lynch, PhD., J.R. Ives, BS., A.B. Dollins, PhD., C. Morabito, BS., J.K. Matheson, MD., D.L. Schomer, MD., Sleep-Inducing Effects of Low Doses of Melatonin Ingested in the Evening. Clinical Pharmacology & Therapeutics, 1995. 57(5): p. 552-558. Cagnacci A., R. Soldani, S. Yen, Exogenous Melatonin Enhances Luteinizing Hormone Levels of Women in the Follicular but not in the Luteal Menstrual Phase. Fertility and Sterility, 1996. 63 No. 5 (May): p. 996-999. Driessch, V.d.A.M., R. Small, M. Cohen, Safety Aspects and Adverse Experiences with a Melatonin-Norethindrone Combination as Oral Contraceptive. Abstracs, 1996: p. 67-71. Sandyk Reuven, P.G.A., P.A. Anninos, N. Tsagas, Is Postmenopausal Osteoporosis Related to Pineal Gland Funtions? Intern. J. Neuroscience, 1992. 62: p. 15-225. Voordouw B., C G, R. Euser, R. E. R. Verdonk, B. Th. Alberda, F. H. DeLong, A.A.T.C. Drogendijk, B. C. J. M. Fauser, M. Cohen, Melatonin and Melatonin-Progestin Combinations Alter Pituitary-Ovarian Function in Woman Can Inhibit Ovulation. Journal of Clinical Endocrinology and Metabolism, 1992. 74 No. 1: p. 108-117. Reiter R.J., Funtional Pleitropy of the Neurohormone Melatonin: Antioxidant Protection and Neuroendocrine Regulation. Frontiers in Neuroendocrinology, 1995. 16: p. 383-415. Lissoni P., A. Ardizzoia, S. Barni, F. Brivo, E. Tisi, F. Robellio, G. Tacini, G. Maestroni, L. Fumagalli, Efficacy and Tolerability of Cancer Neroimmunotherapy with Subcutaneos... Interleukin-2 and the Pineal Hormone Melatonin: A Progress Report of 200 Patients with Advanced Solid Neoplasms. Oncology Reports, 1995. 3: p. 1063-1068. Lissoni P., S. Barni, S. Meregalli, V. Fossati, M. Cazzaniga, D. Esposti, G. Tancini, Modulation of Cancer Endocrine Therapy by Melatonin: A Phase II Study of Tamoxifen Plus Melatonin in Metastic Breast Cancer Patients Progressing Under Tamoxifen Alone. British Journal of Cancer, 1995. 71: p. 854-856. Morrey K. M., J. A. McLachlan, C. D. Serkin, O. Bakouche, Activation of Human Monocytes by the Pineal Hormone Melatonin. J. Immunol, 1994. 153(6): p. 2671. Hattori A., H. Migitaka, M. Iigo, M. Itoh, K. Tamamoto, R. Ohtani-Kaneko, M. Hara, T. Suzuki, R.J. Reiter, Identification of Melatonin in Plants and its Effect on Plasma Melatonin Levels and Binding to Melatonin Receptors in Vertebrates. Biochemistry and Molecular Biology International. 1995. 35: p. 627-634.
|