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LeptinSome studies have suggested that falling leptin levels by starvation (calorie restriction) activate the hypothalamic-pituitary-adrenal axis, and suppress gonadal, somatotropic, and thyroid axes as a response for adaptation. Furthermore, some researchers suggests that this effect is a critical neuroendocrine modulator in the antiaging action of dietary restriction. Research on neuroendocrine mechanisms of calorie restriction is needed, because such efforts might provide clues to the regulation of the aging process in humans. Evolutional theories of aging in animals predict the presence of neuroendocrine signals to divert energy-costly physiologic processes such as reproduction to those essential for survival in response to calorie restriction, and leptin may have a key role in this neuroendocrine adaptation process. Leptin - StudiesA role for leptin in the antiaging action of dietary restriction: a hypothesis. Shimokawa I, Higami Y. Aging (Milano). 1999 Dec;11(6):380-2. Leptin signaling and aging: insight from caloric restriction. Shimokawa I, Higami Y. Mech Ageing Dev. 2001 Sep 30;122(14):1511-9. Leptin and anti-aging action of caloric restriction. Shimokawa I, Higami Y. J Nutr Health Aging. 2001;5(1):43-8. The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men. Chan JL, Heist K, DePaoli AM, Veldhuis JD, Mantzoros CS. J Clin Invest. 2003 May;111(9):1409-21. Role of leptin in the neuroendocrine response to fasting. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS. Nature. 1996 Jul 18;382(6588):250-2.
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