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L-MethionineAs an amino acid, the compound is a precursor in protein synthesis, but also participates in the production of S-adenosylmethionine (SAM or SAMe), L-cysteine, glutathione, taurine and sulfate. It is important to note that SAM is involved in the synthesis of creatine, epinephrine, melatonin and the polyamines spermine and spermidine, among several other substances important from anti aging perspective. It has also been suggested that L-Methionine may act as a antioxidant in the body, which appear to account for its possible anti-hepatotoxic activity. Research suggests that methionine has antioxidant activity by virtue of its sulfur, as well as its chelating ability. However, much research is still needed into the anti aging perspective of L-Methionine, especially as one of the metabolites of L-methionine, L-homocysteine, has been implicated as a significant factor in coronary heart disease and other vascular diseases. L-Methionine - StudiesBellone J, Farello G, Bartoletta E, et al. Methionine potentiates both basal and GHRH-induced GH secretion in children. Clin Endocrinol (Oxf). 1997; 47:61-64. Breillot F, Hadida F, Echinard-Darin P, et al. Decreased rat rhabdomyosarcoma pulmonary metastases in response to low methionine diet. Anticanc Res. 1986; 76:6299-639. Duranton B, Freund JN, Galluser M, et al. Promotion of intestinal carcinogenesis by dietary methionine. Carcinogenesis. 1999; 20:493-497. Hladovec J, Sommerova Z, Pisarikova A. Homocysteinemia and endothelial damage after methionine load. Thrombo Res. 1997; 88:361-364. Jones AL, Hayes PC, Proudfoot AT, Vale JA, Prescott LF, Krenzelok EP. Should methionine be added to every paracetamol tablet? BMJ. 1997; 315:301-304. Kroger H, Hauschild A, Ohde M, et al. Nicotinamide and methionine reduce the liver toxic effects of methotrexate. Gen Pharmacol. 1999; 33:203-206. La Vecchia C, Negri E, Franceschi S, Decarli A. Case-control study on influence of methionine, nitrite, and salt on gastric carcinogenesis in northern Italy. Nutr Canc. 1997; 27:65-68. Meakins TS, Persaud C, Jackson AA. Dietary supplementation with L-methionine impairs the utilization of urea-nitrogen and increases 5-L-oxoprolinuria in normal women consuming a low protein diet. J Nutr 1998; 128:720-727. Sha S-H, Schacht J. Antioxidants attenuate gentamicin-induced free radical formation in vitro and ototoxicity in vivo: D-methionine is a potential protectant. Hearing Res. 2000; 142:34-40. Vale JA, Meredith TJ, Goulding R. Treatment of acetaminophen poisoning. The use of oral methionine. Arch Int Med. 1981; 141(3 Spec No):394-396.
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