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KinetinMost of the research data points towards the compound acting as a strong antioxidant in vitro and in vivo. Interestingly from anti aging viewpoint, the compound was found on human fibroblasts to both delay the onset and decrease the extent of many of the ageing characteristics that appear during serial passaging of normal cells in culture. Furthermore, these effects were most pronounced in cultures in which the compound was present continuously on the culture medium. Upon removal of kinetin, some ageing characteristics began to reappear within a few population doublings. The compound reacts with glycoxidized proteins and possesses anti-oxidant activity, which are similar characteristics to three other anti aging compounds under current research, aminoguanidine, N-t-butylhydroxylamine, and carnosine. In terms of life extension, research with low levels of kinetin added to the diet of fruitflies has raised the maximum age of the most elderly male flies from 70 days in the control group vs 79 d in Kinetin group, and in the most elderly females 76 days vs 91 days. Kinetin - StudiesRattan Sis. N-6-furfuryladenine (kinetin) as a potential anti-aging molecule. Journal of Anti-Aging Medicine 2002, 5 (1): 113-116. Barciszewski J, Siboska GE, Pedersen BO, Clark BFC, Rattan SIS (1996. ) Evidence for the presence of kinetin in DNA and cell extracts. FEBS Lett 393: 197–200 . Barciszewski J, Siboska GE, Pedersen BO, Clark BFC, Rattan SIS (1997. ) A mechanism for the in vivo formation of N6-furfuryladenine, kinetin, as a secondary oxidative damage product of DNA. FEBS Lett 414: 457–460. Barciszewski J, Siboska G, Rattan SIS, Clark BFC (2000a. ) Occurrence, biosynthesis and properties of kinetin (N-6-furfuryladenine). Plant Growth Reg 32: 257–265. Barciszewski J, Siboska G, Clark BFC, Rattan SIS (2000b. ) Cytokinin formation by oxidative metabolism. J Plant Physiol 157: 587–588. Hipkiss AR (2001. ) On the “struggle between chemistry and biology during aging”—implications for DNA repair, apoptosis and proteolysis, and a novel route of intervention. Biogerontology 2: 173–178. Hsiao G, Shen MY, Lin KH, Chou CY, Tzu NH, Lin CH, Chou DS, Chen TF, Sheu JR (2003. ) Inhibitory activity of kinetin on free radical formation of activated platelets in vitro and on thrombus formation in vivo. Eur J Pharm 465: 281–287. Ishii Y, Hori Y, Sakai S, Honma Y (2002. ) Control of differentiation and apoptosis of human myeloid leukemia cells by cytokinins and cytokinin nucleosides, plant redifferentiation-inducing hormones. Cell Growth Diff 13: 19–26 [PubMed]. Leshem YY (1988. ) Plant senescence processes and free radicals. Free Radical Biol Med 5: 39–49 [PubMed]. Miller CO, Skoog F, Von Saltza MH, Strong M (1955. ) Kinetin, a cell division factor from deoxyribonucleic acid. J Am Chem Soc 77: 1329–1334. Olsen A, Siboska GE, Clark BFC, Rattan SIS (1999. ) N-6-furfuryladenine, kinetin, protects against Fenton reaction-mediated oxidative damage to DNA. Biochem Biophys Res Comm 265: 499–502. Rattan SIS (2002. ) N-6-furfuryladenine (kinetin) as a potential anti-aging molecule. J Anti-Aging Med 5: 113–116. Rattan SIS, Clark BFC (1994. ) Kinetin delays the onset of aging characteristics in human fibroblasts. Biochem Biophys Res Comm 201: 665–672. Sharma SP, Kaur P, Rattan SIS (1995. ) Plant-growth hormone kinetin delays aging, prolongs the life-span and slows down development of the fruit-fly Zaprionus paravittiger. Biochem Biophys Res Comm 216: 1067–1071. Sharma SP, Kaur J, Rattan SIS (1997. ) Increased longevity of kinetin-fed Zaprionus fruitflies is accompanied by their reduced fecundity and enhanced catalase activity. Biochem Mol Biol Intl 41: 869–875. Verbeke P, Siboska GE, Clark BFC, Rattan SIS (2000. ) Kinetin inhibits protein oxidation and glycoxidation in vitro. Biochem Biophys Res Comm 276: 1265–1270.
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