 |
IronThe compound is a mineral that the body requires for essential proteins, such as microsomal electron transport proteins and iron-sulfur proteins and enzymes such as ribonucleotide reductase. However, at it's core, the essentiality of the compound is in its capacity to participate in one-electron exchange reactions. The downside of this property is that it generates free radicals that can be harmful to cells. Therefore, excess of iron in the body is associated with generation of oxidative stress, due to high concentration of oxygen radical intermediates. Therefore, in anti aging regimens, many control their levels of the compound in order to avoid situations that are detrimental to health. Iron - StudiesGhio, A.J., Kennedy, T.P., Crissman, K.M., Richards, J.H., Hatch, G.E. Depletion of iron and ascorbate in rodents diminishes lung injury after silica. Exp. Lung Res. 1998 Mar-Apr; 24(2): 219-32. Milchak, L.M., Douglas Bricker, J. The effects of glutathione and vitamin E on iron toxicity in isolated rat hepatocytes. Toxicol. Lett. 2002 Feb 7; 126(3): 169-77. Muller, U., Krieglstein, J. Prolonged pretreatment with alpha-lipoic acid protects cultured neurons against hypoxic, glutamate-, or iron-induced injury. J. Cereb. Blood Flow Metab. 1995 Jul; 15(4): 624-30. Pietrangelo, A., Borella, F., Casalgrandi, G., Montosi, G., Ceccarelli, D., Gallesi, D., Giovannini, F., Gasparetto, A., Masini, A. Antioxidant activity of silybin in vivo during long-term iron overload in rats. Gastroenterology 1995 Dec; 109(6): 1941-9. Tjalkens, R.B., Valerio, L.G., Jr., Awasthi, Y.C., Petersen, D.R. Association of glutathione S-transferase isozyme-specific induction and lipid peroxidation in two inbred strains of mice subjected to chronic dietary iron overload. Toxicol. Appl. Pharmacol. 1998 Jul; 151(1): 174-81.
|