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Huperzine AMore acetylcholine becomes available to stimulate neurons as the actions of acetylcholinesterase are inhibited. In research, the huperzine extract (from a club moss (Huperzia serrata)) has also been found to be beneficial in patients with Alzheimer’s disease. Alzheimer’s disease is a condition where there’s a relative shortage of acetylcholine, which might explain the suggestions of positive effect. Studies also have shown promise that the extract might have positive impact on improvement in memory, cognition, and behavioral functions. Huperzine A - StudiesHuperzine A. Drugs R D. 2004;5(1):44-5. Clinical efficacy and safety of huperzine Alpha in treatment of mild to moderate Alzheimer disease, a placebo-controlled, double-blind, randomized trial. Zhonghua Yi Xue Za Zhi. 2002 Jul 25;82(14):941-4. Comparative effects of huperzine A, donepezil and rivastigmine on cortical acetylcholine level and acetylcholinesterase activity in rats. Neurosci Lett. 2004 May 6;361(1-3):56-9.
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