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Heart Rate Variability

Heart rate variability (HRV) has potential for usage as a measurement of fitness and for providing indications of possible cardiac diseases.

HRV is the variation of beat-to-beat intervals of the heart.

A healthy heart has a large HRV, while decreased or absent variability may indicate cardiac disease.

As a marker of cumulative wear and tear, HRV has been shown in research to decline with the aging process.

Although resting heart rate does not change significantly with advancing age, there is a decline in HRV, which has been attributed to a decrease in efferent vagal tone and reduced beta-adrenergic responsiveness.

Regular moderate physical activity (which slows down the aging process) has been shown in research to raise HRV, presumably by increasing vagal tone.

It has been suggested by some that HRV could be part of a serious anti aging regimen as a biomarker of aging, and as a way to monitor the effectiveness of anti aging exercise, for example.

Heart Rate Variability - Studies

Cohen, H., Matar, M. A., Kaplan, Z., & Kotler, M. (1999). Power spectral analysis of heart rate variability in psychiatry. Psychotherapy and Psychosomatics, 68, 59-66.

Cohen, H., Kotler, M., Matar, M. A., Kaplan, Z., Loewenthal, U., Midodownik, H., & Cassuto, Y. (1998). Analysis of heart rate variability in posttraumatic stress disorder patients in response to a trauma-related reminder. Biological Psychiatry, 44, 1054-1059.

Cohen, H., Kotler, M., Matar, M. A., Kaplan, Z., Miodownik, H., & Cassuto, Y. (1997). Power spectral analysis of heart rate variability in posttraumatic stress disorder patients. Biological Psychiatry, 41, 627-629.

Cowen, M. J., Kogan, H., Burr, R., Hendershot, S., & Buchanan, L. (1990). Power spectral analysis of heart rate variability after biofeedback training. Journal of Electrocardiology, 23, 85-94.

Hirsch, J. A., & Bishop, B. (1981). Respiratory sinus arrhythmia in humans: How breathing pattern modulates heart rate. American Journal of Physiology, 241, H620-H629.

Ichiro, K., Sparrow, D., Pantel, V., & Weiss, S. T. (1995). Decreased heart rate variability in men with phobic anxiety (data from the normative aging study). American Journal of Cardiology, 75, 882-885.

Kleiger, R. E. et al. (1991). Stability over time of variables measuring heart rate variability in normal subjects. American Journal of Cardiology, 68, 626-630.

Klein, E., Cnaani, E., Harel, T., Braun, S., & Ben-Haim, S. A. (1995). Altered heart rate variability in panic disorder patients. Biological Psychiatry, 37, 18-24.

Lohr, J. M., Lilienfeld, S. O., Tolin, D. F., & Herbert, J. D. (1999). Eye movement desensitization and reprocessing: An analysis of specific versus nonspecific treatment effects. Journal of Anxiety Disorders, 13, 185-207.

Moser, M., Lehofer, M., Howhn-Saric, R., McLeod, D. R., Hildebrandt, G., Steinbrenner, B., Voica, M., Liebmann, R., & Zapotoczky, H. (1998). Increased heart rate in depressed subjects in spite of unchanged autonomic balance? Journal of Affective Disorders, 48, 115-124.

Pomeranz, B. et al. (1985). Assessment of autonomic function in humans by heart rate spectral analysis. American Journal of Physiology, 248, H151-H153.

Roose, S. P., et al. (1998). Comparison of proxetine and nortriptyline in depressed patients with ischemic heart disease. JAMA, 279, 287-291.

Ross, S., & Buckalew, L. W. (1985). Plaecbo agentry: Assessment of drug and placebo effects. In Placebo: Theory, research, and mechanism, L. White, B. White, & G. Schwartz (Eds.). New York: Guildord, 67-82.

Yeragani, V. K., Balon, R., Pohl, R., & Ramesh, C. (1995). Depression and heart rate variability. Biological Psychiatry, 38, 768-770.

Grossman P. Respiratory and cardiac rhythms as windows to central and autonomic biobehavioral regulation: Selection of window frames, keeping the panes clean and viewing neural topography. Biological Psychology 1992; 34: 131-161.

Haines AP, Imeson JD, Meade TW. Phobic anxiety and ischaemic heart disease. Br Med J 1987; 295: 297-299.

Kawachi I, Colditz GA, Ascherio A, Rimm EB, Giovannucci E, Stampfer MJ, Willett WC. Prospective study of phobic anxiety and risk of coronary heart disease. Circulation 1994a; 89: 1992-1997.

Kawachi I, Sparrow D. Vokonas PS, Weiss ST. Symptoms of anxiety and risk of coronary heart disease: The Normative Aging Study. Circulation 1994b; 90: 2225-2229.

Kawachi I, Sparrow D, Vokonas PS, Weiss ST. Decreased heart rate variability in men with phobic anxiety. Am J Cardiol 1995; 75: 882-885.

Kristal-Boneh E, Raifel M, Froom P, Ribak J. Heart rate variability in health and disease. Scan J Work Environ Health 1995; 21: 85-95.

Mittleman MA, Maclure M, Sherwood JB, Mulry RP, Tofler GH, Jacobs SC, Friedman R, Benson H, Muller JE. Triggering of acute myocardial infarction onset by episodes of anger. Circulation 1995; 92: 1720-1725.

Offerhaus RE. Heart rate variability in psychiatry. In: RJ Kitney, Rompelman O (eds). The Study of Heart Rate Variability. Oxford: Oxford University Press, 1980: 225-238.

Sloan RP, Shapiro PA, Bigger T Jr, Bagiella E, Steinman RC, Gorman JM. Cardiac autonomic control and hostility in healthy subjects. Am J Cardiol 1994; 74: 298-300.

Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Circulation 1996; 93: 1043-65.

Yeragani VK, Balon R, Pohl R, Ramesh C, Glitz D, Weinberg P, Merlos B. Decreased R-R variance in panic disorder patients. Acta Psychiatr Scand 1990; 81: 554-559.

Yeragani VK, Pohl R, Berger R, Balon R, Ramesh C, Glitz D, Srinivasan K, Weinberg P. Decreased heart rate variability in panic disorder patients: a study of power-spectral analysis of heart rate. Psychiatry Res 1993; 46: 89-103.


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