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Growth Hormone TherapyThe main idea behind hormone replacement therapies for anti aging purpose reflects the thinking and theory that aging is a disease characterized by declining hormonal health. For growth hormone, production rate has been suggested by research to decrease by 14% every decade into old age and from the peak that occurs during adolescence. For some cause that has not been identified as of yet, the pituitary gland ceases to secrete the hormone gradually, which tells the body to repair the cells. It has been suggested that a 60 year old man secretes 25% of the hGH secreted by a 20 year old man. The widespread use replacement therapy with human growth hormone started after 1989, when a landmark double blind study by Dr. Daniel Rudman was published. The results of this study conclusively showed that with the use of growth hormone, age reversal (as measured by thicker skin, bigger muscles, diminished age-related stomach fat, restoration of lost bone from spine) was possible. In subsequent research, four methods have been identified for increasing the level of human growth hormone in the body: Direct human growth hormone injections For this therapy, there are significant risks associated, and there may be significant risks that have not been discovered in studies. Growth Hormone Therapy - StudiesBlackman et al, "Growth Hormone and Sex Steroid Administration in Healthy Aged Women and Men," J Amer Med Assn, vol, 288 no. 18, Nov. 13, 20. Rudman D, Feller AG, Nagraj HS, Lalitha PY, Goldberg AF, Schlenker RA, Cohn L, Rudman IW, Mattson DE. "Effects of human growth hormone in men over 60 years old," N Engl J Med, 1990 Jul 5:323(1):1-6. Ezzat S, Fear S, Gaillard RC, Gayle C, Landy H, Marcovitz S, Mattioni T, Nussey S, Rees A, Svanberg E. Gender-specific responses of lean body composition and non-gender-specific cardiac function improvement after GH replacement in GH-deficient adults. J Clin Endocrinol Metab. 2002 Jun;87(6):2725-33. Attanasio AF, Bates PC, Ho KK, Webb SM, Ross RJ, Strasburger CJ, Bouillon R, Crowe B, Selander K, Valle D, Lamberts SW; The Hypoptiuitary Control and Complications Study International Advisory Board Human growth hormone replacement in adult hypopituitary patients: long-term effects on body composition and lipid status--3-year results from the HypoCCS Database. J Clin Endocrinol Metab. 2002 Apr;87(4):1600-6. Gotherstrom G, vensson J, Koranyi J, Alpsten M, Bosaeus I, Bengtsson B, Johannsson G, "A prospective study of 5 years of GH replacement therapy in GH-deficient adults: sustained effects on body composition, bone mass, and metabolic indices," J Clin Endocrinol Metab. 2001 Oct;86(10):4657-65. Gillberg P, Bramnert M, Thoren M, Werner S, Johannsson G, "Commencing growth hormone replacement in adults with a fixed low dose. Effects on serum lipoproteins, glucose metabolism, body composition, and cardiovascular function," Growth Horm IGF Res. 2001 Oct;11(5):273-81. Hernberg-Stahl E, Luger A, Abs R, Bengtsson BA, Feldt-Rasmussen U, Wilton P, Westberg B, Monson JP; KIMS International Board., KIMS Study Group. Pharmacia International Metabolic Database, "Healthcare consumption decreases in parallel with improvements in quality of life during GH replacement in hypopituitary adults with GH deficiency," J Clin Endocrinol Metab. 2001 Nov;86(11):5277-81. Herschbach P, Henrich G, Strasburger CJ, Feldmeier H, Marin F, Attanasio AM, Blum WF. Development and psychometric properties of a disease-specific quality of life questionnaire for adult patients with growth hormone deficiency. Eur J Endocrinol. 2001 Sep;145(3):255-65. Ahmad AM, Hopkins MT, Thomas J, Ibrahim H, Fraser WD, Vora JP. Body composition and quality of life in adults with growth hormone deficiency; effects of low-dose growth hormone replacement. Clin Endocrinol (Oxf). 2001 Jun;54(6):709-17.
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