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GraviolaHowever, there have been no human or animal studies done on the extract to validate these findings. The extract from the tree has a long list of potential active compounds, including acetogenins and muricins. Before anything confident can be said about the extract, more studies need to take place. However, so far, the extract has shown promise in several areas in laboratory research. However, it should be noted that some researchers have raised concern that consuming the graviola fruit for prolonged periods may increase the risk for a form of Parkinson's Disease. Graviola - StudiesProximate composition and selected physicochemical properties of the seed, pulp and oil of sour sop (Annona muricata - graviola ). Plant Foods Hum Nutr. 2002 Spring;57(2):165-71. Effect of the extract of Annona muricata ( graviola extract ) and Petunia nyctaginiflora on Herpes simplex virus. J Ethnopharmacol. 1998 May;61(1):81-3. Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in Guadeloupe. J Neurochem. 2004 Jan;88(1):63-9. The mitochondrial complex I inhibitor annonacin is toxic to mesencephalic dopaminergic neurons by impairment of energy metabolism. Neuroscience. 2003;121(2):287-96. Cytotoxicity and antileishmanial activity of Annona muricata pericarp - graviola. Fitoterapia. 2000 Apr;71(2):183-6. Two new mono-tetrahydrofuran ring acetogenins, annomuricin E and muricapentocin, from the leaves of Annona muricata - graviola. J Nat Prod. 1998 Apr;61(4):432-6. Isoquinoline derivatives isolated from the fruit of Annona muricata ( graviola ) as 5-HTergic 5-HT1A receptor agonists in rats: unexploited antidepressive (lead) products. J Pharm Pharmacol. 1997 Nov;49(11):1145-9. Five new monotetrahydrofuran ring acetogenins from the leaves of Annona muricata - graviola. J Nat Prod. 1996 Nov;59(11):1035-42. Five novel mono-tetrahydrofuran ring acetogenins from the seeds of Annona muricata ( graviola ). J Nat Prod. 1996 Feb;59(2):100-8. Muricatocins A and B, two new bioactive monotetrahydrofuran Annonaceous acetogenins from the leaves of Annona muricata (graviola). J Nat Prod. 1995 Jun;58(6):902-8. Two new cytotoxic monotetrahydrofuran Annonaceous acetogenins, annomuricins A and B, from the leaves of Annona muricata ( graviola ). J Nat Prod. 1995 Jun;58(6):830-6. Screening of Brazilian fruit aromas using solid-phase microextraction-gas chromatography-mass spectrometry. J Chromatogr A. 2000 Mar 17;873(1):117-27.
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