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Gotu KolaIn research with animals, the herb extract, as an oral treatment of a methanol extract for 14 days, was found to significantly increase anti-oxidant enzymes such as superoxide dismutase (SOD), catalase and glutathione peroxidase (GSHPx). In studies with mice, the herb has also been associated with antidepressant and anti-ulcer abilities. There are several potential chemicals found in the herb that may contribute to the positive health effects, including alkaloids, triterpenes, sterols, tannins, and glycosides. In addition to the reported potential health benefits, some use stimulants such as Gotu Kola and Ginseng to replace caffeine in their diet. Gotu Kola - StudiesEffect of total triterpenes from Centella asiatica (gotu kola) on the depression behavior and concentration of amino acid in forced swimming mice. Zhong Yao Cai. 2003 Dec;26(12):870-3. The healing effects of Centella extract - gotu kola - and asiaticoside on acetic acid induced gastric ulcers in rats. Life Sci. 2004 Mar 19;74(18):2237-49. Adjunctive periodontal treatment with Centella asiatica (gotu kola) and Punica granatum extracts. A preliminary study. J Int Acad Periodontol. 2003 Oct;5(4):106-15. Treatment of edema and increased capillary filtration in venous hypertension with total triterpenic fraction of Centella asiatica (gotu kola): a clinical, prospective, placebo-controlled, randomized, dose-ranging trial. Angiology. 2001 Oct;52 Suppl 2:S55-9. A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects. J Clin Psychopharmacol. 2000 Dec;20(6):680-4.
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