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GABAAs a dietary supplement, there has been controversy around its effectiveness as the compound cannot easily cross the blood-brain barrier. Current manufacturer research tries to overcome this obstacle by researching ways to place GABA in an oil base in order to ease its entry across that barrier. In one study done by the First Medical Clinic at the University of Milan, Italy, GABA was shown to stimulates the anterior pituitary, leading to higher levels of human growth hormone, a compound which has anti aging effects on the human body. GABA - StudiesEffect of Acute and Repeated Administration of Gamma Aminobutyric Acid (GABA) on Growth Hormone and Prolactin Secretion in Man. Cavagnini F, Invitti C, Pinto M, Maraschini C, Di Landro A, Dubini A, Marelli A. Acta Endocrinol (Copenh) 1980 Feb;93(2):149-54. Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans. Biofactors. 2006;26(3):201-8. Department of Research and Development, Pharma Foods International Co. Ltd., Kyoto, Japan. Alcohol effects on gamma-aminobutyric acid type A receptors: are extrasynaptic receptors the answer? Life Sci. 2004 Nov 19;76(1):1-8. GABA inhibits T cell autoimmunity and the development of inflammatory responses in a mouse type 1 diabetes model. J Immunol. 2004 Oct 15;173(8):5298-304. Effect of a gamma-aminobutyric acid-enriched dairy product on the blood pressure of spontaneously hypertensive and normotensive Wistar-Kyoto rats. Br J Nutr. 2004 Sep;92(3):411-7. Molecular structure and physiological functions of GABA (B) receptors. Physiol Rev. 2004 Jul;84(3):835-67. Acupuncture-mediated inhibition of ethanol-induced dopamine release in the rat nucleus accumbens through the GABA B receptor. Neurosci Lett. 2004 Oct 21;369(3):234-8. GABA pharmacology-what prospects for the future? Biochem Pharmacol. 2004 Oct 15;68(8):1537-40. A role for GABA mechanisms in the motivational effects of alcohol. Biochem Pharmacol. 2004 Oct 15;68(8):1515-25. [Comparative study of the effect of picamilone and piracetam on learning in rats in a radial maze] Farmakol Toksikol. 1989 Jul-Aug;52(4):14-7. Involvement of growth hormone-releasing factor in growth hormone secretion induced by gamma-aminobutyric acid in conscious rats. Murakami Y, 1985 Endocrinology 117(2), 787-789 (1985). Evidence for a GABAergic control of the exercise-induced rise in GH in man. Steardo L, Iovino M, Monteleone P, Agrusta M, Orio F Eur J Clin Pharmacol 28 (5): 607-609 (1985). Growth hormone secretion of the neonatal rat pituitaries is stimulated by gamma-aminobutyric acid in vitro. Acs Z, Makara GB, Stark E Life Sci 34 (16): 1505-1511 (Apr 1984). Gamma aminobutyric acid (GABA), a modulator of anterior pituitary hormone secretion by hypothalamic and pituitary action. McCann SM, Vijayan E, Negro-Vilar A, Mizunuma H, Mangat H Psychoneuroendocrinology 9 (2): 97-106 (1984). Effect of gamma-aminobutyric acid on growth hormone and prolactin secretion in man: influence of pimozide and domperidone. Cavagnini F, Benetti G, Invitti C, Ramella G, Pinto M, Lazza M, Dubini A, Marelli A, Muller EE J Clin Endocrinol Metab 51 (4): 789-792 (Oct 1980). Effects of some gamma-aminobutyric acid (GABA)-ergic drugs on the dopaminergic control of human growth hormone secretion. Koulu M, Lammintausta R, Dahlstrom S J Clin Endocrinol Metab 51 (1): 124-129 (Jul 1980) Growth hormone release by gamma-aminobutyric acid (GABA) and gamma-amino-beta-hydroxybutyric acid (GABOB) in the rat. Abe H, Kato Y, Chihara K, Ohgo S, Iwasaki YEndocrinol Jpn 24 (2): 229-231 (Apr 1977). Regulation of growth hormone secretion Kato Y, Chihara K, Daigo S, Iwasaki Y, Abe H Horumon To Rinsho 25 (2): 131-141 (Feb 1977). Pharmacological evidence for a dual GABAergic regulation of growth hormone release in humans. Steardo L, Iovino M, Monteleone P, Agrusta M, Orio F Life Sci 39 (11): 979-985 (Sep 1986). Involvement of alpha-adrenergic and GABAergic mechanisms in growth hormone secretion induced by central somatostatin in rats. Murakami Y, Kato Y, Koshiyama H, Inoue T, Ishikawa Y, Imura H Brain Res 407 (2): 405-408 (Mar 1987). Evidence for a sex difference in the basal growth hormone response to GABAergic stimulation in humans. Monteleone P, Maj M, Iovino M, Steardo L Acta Endocrinol (Copenh) 119 (3): 353-357 (Nov 1988). Role of hypothalamic factors (growth-hormone-releasing hormone and gamma-aminobutyric acid) in the regulation of growth hormone secretion in the neonatal and adult rat. Acs Z, Lonart G, Makara GB Neuroendocrinology 52 (2): 156-160 (Aug 1990). Possible mediation of GABA induced growth hormone secretion by increased calcium-flux in neonatal pituitaries. Acs Z, Zsom L, Makara GB Life Sci 50 (4): 273-279 (1992). Potent agonists of growth hormone-releasing hormone. II. Zarandi M, Serfozo P, Zsigo J, Deutch AH, Janaky T, Olsen DB, Bajusz S, Schally AV Pept Res 5 (4): 190-193 (Jul 1992). New Gaba-containing analogues of human growth hormone-releasing hormone (1-30)-amide: I. Synthesis and in vitro biological activity. Mezo I, Kovacs M, Szoke B, Szabo EZ, Horvath J, Makara GB, Rappay G, Tamas J, Teplan I J Endocrinol Invest 16 (10): 793-798 (Nov 1993). Neuroendocrine regulation of growth hormone secretion in sheep. VII. Effects of GABA. Spencer GS, Berry CJ, Bass JJ Regul Pept 52 (3): 181-186 (Aug 1994). Growth hormone secretion and activation of cyclic AMP by growth hormone releasing hormone and gamma-aminobutyric acid in the neonatal rat pituitary. Mergl Z, Acs Z, Makara GB Life Sci 56 (8): 579-585 (1995).
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