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Ferulic AcidAs an antioxidant, the compound is also associated with reducing the levels of cholesterol and triglyceride, thus reducing the risk of hearth disease. Specific animal studies and in vitro studies on the compound suggest that it may have direct antitumor activity against breast cancer and liver cancer. The compound has been suggested to have pro-apoptotic effects in cancer cells, leading to their destruction. In other studies, the compound has shown promise as being effective at preventing cancer induced by exposure to the carcinogenic compounds benzopyrene and 4-nitroquinoline 1-oxide. However, no controlled human studies have been done so far on these issues, thus leaving the effectiveness in humans unconfirmed. Ferulic Acid - StudiesFerulic acid: an antioxidant found naturally in plant cell walls and feruloyl esterases involved in its release and their applications. Crit Rev Biotechnol. 2004; 24(2-3): 59-83. Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin. J Invest Dermatol. 2005 Oct; 125(4): 826-32. Chemopreventive effects of ferulic acid on oral and rice germ on large bowel carcinogenesis. Anticancer Res. 1999 Sep-Oct; 19(5A): 3775-8. Antiproliferative and apoptotic effects of selective phenolic acids on T47D human breast cancer cells: potential mechanisms of action. Breast Cancer Res. 2004; 6(2: R63-74. Epub 2003 Dec 15. Role of NADPH oxidase-mediated generation of reactive oxygen species in the mechanism of apoptosis induced by phenolic acids in HepG2 human hepatoma cells. Arch Pharm Res. 2005 Oct; 28(10): 1183-9. Protective effects of ellagic acid and other plant phenols on benzo[a]pyrene-induced neoplasia in mice. Carcinogenesis. 1983 Dec; 4(12): 1651-3.
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