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Ellagic AcidSpecifically, studies on the compound have shown promise on inhibiting and stopping mitosis-cancer cell division, and apoptosis (normal cell death) for breast, pancreas, esophageal, skin, colon and prostate cancer cells. Clinical tests also show that the compound has promise on preventitive effect on the destruction of the p53 gene by cancer cells. In dietary sources, the Meeker Red Raspberry is the best source of Ellagic Acid, followed by the Chiliwak and Willamette. Ellagic Acid - StudiesLesca, P: Protective effects of ellagic acid and other plant phenols on benzo(a)pyrene-induced neoplasia in mice. Carcinogenesis 4:1651-1653, 1983. Chang, RL, Hùang, MT; Wood, AW; Wong, CQ; Newmark, HL; Yagi H; Sayer, JM; Conney, AH: Effect of ellagic acid and hydroxylated flavonoids on the tumorigenicity of benzo(a)pyrene and (")-78ß,8a-dihydroxy-9a,10a-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene on mouse skin and in the newborn mouse. Carcinogenesis 6:1127-1133, 1985. Mandal S; Stoner, GD: Inhibition of N-nitrosobenzyl-methylamine-induced esophageal tumorigenesis in rats by ellagic acid. Carcinogenesis 11:55-61, 1990. Daniel, EM; Stoner, GD: The effects of ellagic acid and 13-cis-retinoic acid on N-nitrosobenzylmethylamine-induced esophagal tumorigenesis in rats. Cancer Lett 56:117-124, 1991. Siglin, JC; Barch, DH; Stoner, GD: Effects of phenethyl isothiocyanate, ellagic acid, sulindac and supplementary dietary calcium on the induction and progression of esophageal carcinogenesis in rats induced by short-term administration of N-nitrosomethylbenzylamine. Carcinogenesis, 1995. Tanaka, T; Iwata, H; Niwa, K; Mori, Y; Mori, H: Inhibitory effect of ellagic acid on N-2-fluoenylacetamide-induced liver carcinogenesis in male AC1/N rats. Jpn J Cancer Res (Gann) 79:1297-1303, 1988. Funt, R.C.; Bash, W.D.; Schwartz, S.J; Collier, J and G. Wenneker. 1997. Small fruit cultivar characteristics for ellagic acid and nutraceutical development. Proceedings Ohio Fruit and Vegetable Growers Congress. pp 110-114. Stoner, G.D. and Mukhtar, H. Polyphenols as cancer chemopreventative agents. J. Cellular Biochemistry, Supplement 22: 169-180.
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