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DIMDIM (Diindolylmethane) in studies has increased the specific aerobic metabolism for estrogen, increasing the chance for estrogen to be broken down into its beneficial estrogen metabolites. The compound has been suggested to produce more beneficial estrogen metabolites, which compete with testosterone for protein binding, which can help maintain a slightly higher free testosterone level. This is why some athletes use the supplement for increasing their testosterone levels naturally. Testosterone is an anabolic hormone due to its ability to promote protein synthesis. Studies are also underway in which the components efficiency to provide potential protection against hormone-dependent cancers. DIM - Studies3,3'-diindolylmethane and paclitaxel act synergistically to promote apoptosis in HER2/Neu human breast cancer cells. J Surg Res. 2006 May 15;132(2):208-13. Epub 2006 Mar 31. McGuire KP, et al. Department of Surgery, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. Pilot study: effect of 3,3'- diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Cancer. 2004;50(2):161-7. Dalessandri KM, Firestone GL, Fitch MD, Bradlow HL, Bjeldanes LF. Department of Molecular and Cell Biology, University of California, Berkeley, 94720-3200, USA.
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