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ChrysinIn research, the compound has shown potent anti-inflammation and antioxidant properties. Of these, the antioxidant activity has been shown by its ability to inhibit xanthine oxidase and consequently suppress the formation of uric acid and certain reactive oxygen species. Studies done in Europe have also shown that after supplementing with chrysin blood serum levels of testosterone went up significantly, which has lead to many athletes to use the compound. This effect has been suggested to be due to the compound's possible action in inhibiting the conversions of androgens to estrogens (testosterone to estrogen). However, subsequent studies have failed to register similar changes in testosterone levels. Chrysin - StudiesComparison of high-speed counter-current chromatography instruments for the separation of the extracts of the seeds of Oroxylum indicum. J Chromatogr A. 2005 Jan 21;1063(1-2):241-5. Chrysin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression through the inhibition of nuclear factor for IL-6 (NF-IL6) DNA-binding activity. FEBS Lett. 2005 Jan 31;579(3):705-11. Decreased pro-inflammatory cytokine production by LPS-stimulated PBMC upon in vitro incubation with the flavonoids apigenin, luteolin or chrysin, due to selective elimination of monocytes/macrophages. Biochem Pharmacol. 2005 Jan 15;69(2):241-8. Effects of the dietary flavonoid chrysin in isolated rat mesenteric vascular bed. J Vasc Res. 2004 Nov-Dec;41(6):509-16. Effects of chrysin on urinary testosterone levels in human males.J Med Food. 2003 Winter;6(4):387-90. Beneficial effects of chrysin and benzoflavone on virility in 2-year-old male rats. J Med Food. 2002 Spring;5(1):43-8.
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