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ChromiumFrom anti aging perspective, it is also important to note that the compound has the effect of normalizing blood sugar levels. Chromium is believed to form a component of glucose tolerance factor, responsible for activating insulin receptor kinase, thereby increasing insulin sensitivity. For some researchers, the compound has become an essential tool in their search for remedies in clinical studies for diabetes and obesity. There is evidence that chromium lowers harmful total cholesterol and triglycerides, while raising beneficial HDL cholesterol. One can even find studies that suggest that chromium promotes fat loss and lean muscle mass retention. Chromium - StudiesAnderson RA. Chromium and parenteral nutrition. Nutrition. 1995 Jan-Feb;11(1 Suppl):83-6. Brown RO, Forloines-Lynn S, Cross RE, Heizer WD. Chromium deficiency after long-term total parenteral nutrition. Dig Dis Sci. 1986 Jun;31(6):661-4. Freund H, Atamian S, Fischer JE. 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Concentrations of seven trace elements in different hematological matrices in patients with type 2 diabetes as compared to healthy controls. Biol Trace Elem Res. 2001 Mar;79(3):205-19. Anderson RA. Effects of chromium on body composition and weight loss. Nutr Rev. 1998 Sep;56(9):266-70. Crawford V, Scheckenbach R, Preuss HG. Effects of niacin-bound chromium supplementation on body composition in over- weight African-American women. Diabetes Obes Metab. 1999 Nov;1(6):331-7. Bahadori B, Wallner S, Schneider H, Wascher TC, Toplak H. Effect of chromium yeast and chromium picolinate on body composition of obese, non-diabetic patients during and after a formula diet. Acta Med Austriaca. 1997;24(5):185-7. Kleefstra N, Bilo HJ, Bakker SJ, Houweling ST. Chromium and insulin resistance. Ned Tijdschr Geneeskd. 2004 Jan 31;148(5):217- 20. Lamson DS, Plaza SM. The safety and efficacy of high-dose chromium. Altern Med Rev. 2002 Jun;7(3):218-35. Anderson RA. Recent advances in the clinical and biochemical effects of chromium deficiency. Prog Clin Biol Res. 1993;380:221- 34. Anderson RA. Essentiality of chromium in humans. Sci Total Environ. 1989 Oct 1;86(1- 2):75-81. Anderson RA. Nutritional role of chromium. Sci Total Environ. 1981 Jan;17(1):13-29. Anderson RA. Chromium metabolism and its role in disease processes in man. Clin Physiol Biochem. 1986;4(1):31-41. Anderson RA. Chromium in the prevention and control of diabetes. Diabetes Metab. 2000 Feb;26(1):22-7. Racek J. Chromium as an essential element. Cas Lek Cesk. 2003;142(6):335-9. Appleton DJ, Rand JS, Sunvold GD, Priest J. Dietary chromium tripicolinate supplementation reduces glucose concentrations and improves glucose tolerance in normal-weight cats. J Feline Med Surg. 2002 Mar;4(1):13-25. Shinde Urmila A, Sharma G, Xu YJ, Dhalla NS, Goyal R K. Anti-diabetic activity and mechanism of action of chromium chloride. Exp Clin Endocrinol Diabetes. 2004 May;112(5):248-52. 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Beyond LDL-C — the importance of raising HDL-C. Curr Med Res Opin. 2002;18(1):36-44. Preuss HG, Anderson RA. Chromium update: examining recent literature 1997- 1998. Curr Opin Clin Nutr Metab Care. 1998 Nov;1(6):509-12. Streja D. Combination therapy for the treatment of dyslipidemia. Curr Opin Investig Drugs. 2004 Mar;5(3):306-12. McKenney J. New perspectives on the use of niacin in the treatment of lipid disorders. Arch Intern Med. 2004 Apr 12;164(7):697-705. Rosenson RS. Antiatherothrombotic effects of nicotinic acid. Atherosclerosis. 2003 Nov;171(1):87-96. Wink J, Giacoppe G, King J. Effect of very- low-dose niacin on high-density lipoprotein in patients undergoing long-term statin ther- apy. Am Heart J. 2002 Mar;143(3):514-8. Malik S, Kashyap ML. Niacin, lipids, and heart disease. Curr Cardiol Rep. 2003 Nov;5(6):470-6. Miller M. Niacin as a component of combination therapy for dyslipidemia. Mayo Clin Proc. 2003 Jun;78(6):735-42. Rindone JP, Achacoso S. Effect of low-dose niacin on glucose control in patients with non-insulin-dependent diabetes mellitus and hyperlipidemia. Am J Ther. 1996 Sep;3(9):637-9. Ganji SH, Kamanna VS, Kashyap ML. Niacin and cholesterol: role in cardiovascular disease (review). J Nutr Biochem. 2003 Jun;14(6):298-305. McKenney J. Niacin for dyslipidemia: considerations in product selection. Am J Health Syst Pharm. 2003 May 15;60(10):995-1005. Kruse W, Kruse W, Raetzer H, et al. Nocturnal inhibition of lipolysis in man by nicotinic acid and derivatives. Eur J Clin Pharmacol. 1979 Aug;16(1):11-5. Bays HE, McGovern ME. Once-daily niacin extended release/lovastatin combination tablet has more favorable effects on lipoprotein particle size and subclass distribution than atorvastatin and simvastatin. Prev Cardiol. 2003 Fall;6(4):179-88. Stein EA, Davidson MH, Dujovne CA, et al. Efficacy and tolerability of low-dose Simvastatin and niacin, alone and in combination, in patients with combined hyperlipi- demia: A prospective trial. J Cardiovasc Pharmacol Ther. 1996 Apr;1(2):107-16. Luria MH. Effect of low-dose niacin on high-density lipoprotein cholesterol and total cholesterol/high-density lipoprotein cholesterol ratio. Arch Intern Med. 1988 Nov;148(11):2493-5. Chong PH, Bachenheimer BS. Current, new and future treatments in dyslipidaemia and atherosclerosis. Drugs. 2000 Jul;60(1):55-93. Executive Summary of the Third Report of the Expert Panel on the Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001 May 16;285(19):2486-97. McKenney J. Dyslipidemias. In: Young LY, Koda-Kimble MA, eds. Applied Therapeutics:The Clinical Use of Drugs. 6th ed. Vancouver, WA: Applied Therapeutics Inc; 1995. Vinson JA, Mandarano MA, Shuta DL, Bagchi M, Bagchi D. Beneficial effects of a novel IH636 grape seed proanthocyanidin extract and a niacin-bound chromium in a hamster atherosclerosis model. Mol Cell Biochem. 2002 Nov;240(1-2):99-103. Preuss HG, Wallerstedt D, Talpur N, et al Effects of niacin-bound chromium and grape seed proanthocyanidin extract on the lipid profile of hypercholesterolemic subjects: a pilot study. J Med. 2000;31(5-6):227-46. Leonard SS, Xia C, Jiang BH, et al. Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses. Biochem Biophys Res Commun. 2003 Oct 3;309(4):1017-26. Geetha S, Sai Ram M, Mongia SS, Singh V, Ilavazhagan G, Sawhney RC. Evaluation of antioxidant activity of leaf extract of Seabuckthorn (Hippophae rhamnoides L.) on chromium(VI) induced oxidative stress in albino rats. J Ethnopharmacol. 2003 Aug;87(2-3):247-51. Lopez-Burillo S, Tan DX, Mayo JC, Sainz RM, Manchester LC, Reiter RJ. Melatonin, xanthurenic acid, resveratrol, EGCG, vita- min C and alpha-lipoic acid differentially reduce oxidative DNA damage induced by Fenton reagents: a study of their individual and synergistic actions. J Pineal Res. 2003 May;34(4):269-77. McCarty MF. Longevity effect of chromium picolinate – ‘rejuvenation’ of hypothalamic function? Med Hypotheses. 1994 Oct;43(4):253-65. Franklin M, Odontiadis J. Effects of treat- ment with chromium picolinate on peripheral amino acid availability and brain monoamine function in the rat. Pharmacopsychiatry. 2003 Sep;36(5):176-80.
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