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CatalaseThis result was the study with transgenic mice that overexpress human catalase localized to the mitochondria (MCAT) and supports the free radical theory of aging and reinforces the importance of mitochondria as a source of these radicals. The compound is one of the three major antioxidant enzymes produced by the body in defence against free radical damage, in addition to glutathione peroxidase and superoxide dismutase. Without genetic engineering, there are several compounds that have been linked with increased catalase expression. One group of these compounds are apple polyphenols, especially a compound quercetin, and they were found in a Spanish study released in 2005 to increase glutathione concentration and gene expression of Cu/Zn superoxide dismutase and catalase. The compound has also been linked to deprenyl, which has been shown to boost the production of both Superoxide Dismutase and Catalase. Catalase - StudiesThe Anti-Aging Sweepstakes: Catalase Runs for the ROSes. Richard A. Miller. Science 308 (5730), 1875. Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria. Rabinovitch et al. Science 24 June 2005: Vol. 308. no. 5730, pp. 1909 - 1911. Why (-)deprenyl prolongs survivals of experimental animals: Increase of anti-oxidant enzymes in brain and other body tissues as well as mobilization of various humoral factors may lead to systemic ANTI-AGING effects. Kitani K, Minami C, Isobe K, Maehara K, Kanai S, Ivy GO, Carrillo MC. Mech Ageing Dev 2002, 123 (8): 1087-1100. Procyanidins protect Fao cells against hydrogen peroxide-induced oxidative stress. Roig R, Cascon E, Arola L, Blade C, Salvado MJ. Biochim Biophys Acta. 2002 Aug 15;1572(1):25-30. Influence of quercetin and rutin on growth and antioxidant defense system of a human hepatoma cell line (HepG2). Alia M, Mateos R, Ramos S, Lecumberri E, Bravo L, Goya L. Eur J Nutr. 2005 Mar 25. Reversal of haloperidol-induced orofacial dyskinesia by quercetin, a bioflavonoid. Naidu PS, Singh A, Kulkarni SK. Psychopharmacology (Berl). 2003 Jun;167(4):418-23. The effect of quercetin on the mRNA expression of different antioxidant enzymes in hepatoma cells. Rohrdanz E, Bittner A, Tran-Thi QH, Kahl R. Arch Toxicol. 2003 Sep;77(9):506-10. Epub 2003 May 20. Quercetin, a bioflavonoid, attenuates haloperidol-induced orofacial dyskinesia. Naidu PS, Singh A, Kulkarni SK. Neuropharmacology. 2003 Jun;44(8):1100-6.
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