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Carbonyl DetoxificationDetoxification is important as the accumulation of these toxic substances and their crosslinking products leads to the formation of different age pigments, such as lipofuscin, lens cataracts, and crosslinked collagen. Interestingly, this cleaning process has been linked in research to sleep and melatonin, a pineal gland hormone, which reverses the covalently-bound semi-toxified proteins and nucleic acids. This toxification-cleaning cycle may explain the biochemical necessity for sleep of human and animals during aging. Which is also important to notice is that melatonin levels decrease with aging. If the role of melatonin in cleaning partially glycated proteins hypothesis is correct, it provides a new mechanism to help explain how melatonin protects against such a wide range of age-related diseases. Carbonyl Detoxification - StudiesYin D. Is carbonyl detoxification an important anti-aging process during sleep? Med Hypotheses 2000, 54(4):519-22.
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