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Calorie RestrictionThe research into life extension with calorie restriction has been ongoing since 1930's. The method has been proven successful on worms, spiders, rodents, dogs, cows and monkeys, and by now, the method is believed to be useful for humans as well in terms of anti aging and life extension. In it's most popular form, calorie restriction (eating fewer calories) is complemented with optimal nutrition, that some call CRON (Calorie Restriction with Optimal Nutrition). In this regard, many CR practioners choose to supplement their diet with antioxidant and other anti aging supplements, as well as eat nutritient rich foods for optimal nutrition, as the name suggests. The goal of the method is to achieve people to live longer and healthier lives. It is important to note, as advocated by The Calorie Restriction Society, that simply eating less calories will simply lead to malnutrition, which promotes faster aging process and is not helpful in anti aging efforts. It is often advised that people shift into CR dieting and lifestyle slowly. This is because of two main reasons. For one, there are many pesticides and other toxins in our food supply that are fat soluable. Human bodies store these toxins relatively harmlessly in body fat. If you lose that fat too quickly, however, all these toxins are flushed into your bloodstream, and your detoxificaiton mechanisms are unable to remove them, leaving you with high blood toxin levels, which will have any number of life-shortening effects. It has been known since 1930s that if adult mice were suddenly put on a calorie restricted diet, their lifespans were actually shortened. When further research was done into this, Dr. Walford, one of the pioneers in the field of CR research, found in the 1980s, that if mice were slowly transitioned from an ad lib to a calorie restricted diet, then their lifespans increased. Calorie Restriction - StudiesThe retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. Journal of Nutrition, 116(4), pages 641-54.Weindruch R, et al.,April, 1986. PMID 3958810. 2-Deoxy-D-Glucose Feeding in Rats Mimics Physiological Effects of Caloric Restriction. Mark A. Lane, George S. Roth and Donald K. Ingram in Journal of Anti-Aging Medicine, Vol. 1, No. 4, pages 327--337; Winter 1998. Biomarkers of caloric restriction may predict longevity in humans. Roth GS, Lane MA, Ingram DK, Mattison JA, Elahi D, Tobin JD, Muller D, Metter EJ.: 297: 811, Science 2002. PMID 12161648. Sir2-independent life span extension by calorie restriction in yeast, Kaeberlein, M., K.T. Kirkland, S. Fields, and B.K. Kennedy. 2004. PLoS Biol 2: E296. PMID 15328540. Increased Life Span due to Calorie Restriction in Respiratory-Deficient Yeast, Kaeberlein M, Hu D, Kerr EO, Tsuchiya M, Westman EA, Dang N, Fields S, Kennedy BK. PLoS Genet. 25 November 2005;1(5):e69 Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients, Kaeberlein M, Powers RW 3rd, Steffen KK, Westman EA, Hu D, Dang N, Kerr EO, Kirkland KT, Fields S, Kennedy BK. Science. 18 November 2005;310(5751):1193-6.
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