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BromelainHowever, the most common use of the compound is for the treatment of pain and swelling caused by trauma (including sports injuries, surgery, and infections). Studies have demonstrated the compound's ability to help the body recover from injury more quickly by preventing the accumulation of fibrin and potent inflammatory substances, such as leukotrienes. It has also been suggested that Bromelain inhibits the aggregation of platelets, which has lead to theories that it might help prevent heart disease caused by plaque formation that could lead to a heart attack. The compound seems to interact with a wide variety of other compounds, including ginkgo, saw palmetto, garlic, and vitamin E, as with a wide variety of medications, which causes caution for anyone wishing to use the compound. In terms of enhancing the effectiveness of the compound, potatoes and soybeans may interfere with its absorption and the compound magnesium may increase the effects of Bromelain. Bromelain - StudiesTaussig, S.J., Batkin, S., “Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application.” An Update Journal of Ethnopharmacology 1988;22:191-203. Lotz-Winter, H., “On the pharmacology of bromelain: An update with special regard to animal studies on dose-dependent effects.” Planta Medica 1990;56:249-53. Taussig, S.J., “The mechanism of the physiological action of bromelain” Medical Hypothesis 1980;6:99-104. Ako, H. Cheung, A.H.S., Matsuura, P.K., “Isolation of a fibrinolysis activator from commercial bromelain.” Arch. Int. Pharmacodyn. 1981;284:157-67. Heinicke, R. van der Wal, L. Yokoyama, M., “Effect of bromelain (Ananase®) on human platelet aggregation. ”Experientia 1972;28(7):844. Giller, F.B., “The effects of bromelain on levels of penicillin in the cerebrospinal fluid of rabbits.” A., J. Pharm. 1962;134:238-244. Bodi, T., “The effect of oral bromelain on tissue permeability to antibiotics and pain response to bradykinin; double-blind studies on human subjects.” Clin. Med. 1965;72:61-65.
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