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BoronIn research, the compound has been shown in rats to increase bone strength and studies have suggested it may play a role in improving arthritis, plasma lipid profiles, and brain function. In studies, low boron levels have been associated with low testosterone levels, and subsequent boron supplementation has led to increased serum levels of testosterone in postmenopausal women. This finding has led to a surge in boron supplements for athletes and bodybuilders, but specific research on athletes has not yet confirmed this association that boron alone will boost testosterone. Boron - StudiesDietary boron intake and prostate cancer risk. Oncol Rep. 2004 Apr;11(4):887-92. Cui Y, et al. Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA Plasma boron and the effects of boron supplementation in males. Environ Health Perspect. 1994 Nov;102 Suppl 7:73-7. Green NR, Ferrando AA. Department of Nutrition and Food Science, Auburn University, AL 36849. General, reproductive, developmental, and endocrine toxicity of boronated compounds. Reprod Toxicol. 1998 Jan-Feb;12(1):1-18. Fail PA, et al. Center for Life Sciences and Toxicology, Research Triangle Institute, NC Hideghety K, Sauerwein W, Wittig A, Gotz C, Paquis P, Grochulla F, Haselsberger K, Wolbers J, Moss R, Huiskamp R, Fankhauser H, de Vries M, Gabel D.Tissue uptake of BSH in patients with glioblastoma in the EORTC 11961 phase I BNCT trial.J Neurooncol. 2003 Mar-Apr;62(1-2):145-56. Gibson CR, Staubus AE, Barth RF, Yang W, Ferketich AK, Moeschberger MM.Pharmacokinetics of sodium borocaptate: a critical assessment of dosing paradigms for boron neutron capture therapy.J Neurooncol. 2003 Mar-Apr;62(1-2):157-69. Wallace JM, Hannon-Fletcher MP, Robson PJ, Gilmore WS, Hubbard SA, Strain JJ.Boron supplementation and activated factor VII in healthy men.Eur J Clin Nutr. 2002 Nov;56(11):1102-7. Pan XQ, Wang H, Lee RJ.Boron delivery to a murine lung carcinoma using folate receptor-targeted liposomes.Anticancer Res. 2002 May-Jun;22(3):1629-33. Yanagie H, Kobayashi H, Takeda Y, Yoshizaki I, Nonaka Y, Naka S, Nojiri A, Shinnkawa H, Furuya Y, Niwa H, Ariki K, Yasuhara H, Eriguchi M.Inhibition of growth of human breast cancer cells in culture by neutron capture using liposomes containing 10B.Biomed Pharmacother. 2002 Mar;56(2):93-9. Fort DJ, Rogers RL, McLaughlin DW, Sellers CM, Schlekat CL.Impact of boron deficiency on Xenopus laevis: a summary of biological effects and potential biochemical roles.Biol Trace Elem Res. 2002 Winter;90(1-3):117-42. Review. Armstrong TA, Spears JW.Effect of dietary boron on growth performance, calcium and phosphorus metabolism, and bone mechanical properties in growing barrows.J Anim Sci. 2001 Dec;79(12):3120-7. Kurtoglu V, Kurtoglu F, Coskun B.Effects of boron supplementation of adequate and inadequate vitamin D3-containing diet on performance and serum biochemical characters of broiler chickens.Res Vet Sci. 2001 Dec;71(3):183-7. Smith DR, Chandra S, Barth RF, Yang W, Joel DD, Coderre JA.Quantitative imaging and microlocalization of boron-10 in brain tumors and infiltrating tumor cells by SIMS ion microscopy: relevance to neutron capture therapy.Cancer Res. 2001 Nov 15;61(22):8179-87. Sheng MH, Taper LJ, Veit H, Thomas EA, Ritchey SJ, Lau KH.Dietary boron supplementation enhances the effects of estrogen on bone mineral balance in ovariectomized rats.Biol Trace Elem Res. 2001 Jul;81(1):29-45. Armstrong TA, Spears JW, Lloyd KE.Inflammatory response, growth, and thyroid hormone concentrations are affected by long-term boron supplementation in gilts.J Anim Sci. 2001 Jun;79(6):1549-56. Schaafsma A, de Vries PJ, Saris WH.Delay of natural bone loss by higher intakes of specific minerals and vitamins.Crit Rev Food Sci Nutr. 2001 May;41(4):225-49. Review. Stacewicz-Sapuntzakis M, Bowen PE, Hussain EA, Damayanti-Wood BI, Farnsworth NR.Chemical composition and potential health effects of prunes: a functional food?Crit Rev Food Sci Nutr. 2001 May;41(4):251-86. Review. Sheng MH, Taper LJ, Veit H, Qian H, Ritchey SJ, Lau KH.Dietary boron supplementation enhanced the action of estrogen, but not that of parathyroid hormone, to improve trabecular bone quality in ovariectomized rats.Biol Trace Elem Res. 2001 Summer;82(1-3):109-23. Armstrong TA, Spears JW, Crenshaw TD, Nielsen FH.Boron supplementation of a semipurified diet for weanling pigs improves feed efficiency and bone strength characteristics and alters plasma lipid metabolites.J Nutr. 2000 Oct;130(10):2575-81. Fort DJ, Stover EL, Strong PL, Murray FJ, Keen CL.Chronic feeding of a low boron diet adversely affects reproduction and development in Xenopus laevis.J Nutr. 1999 Nov;129(11):2055-60. Gaby AR.Natural treatments for osteoarthritis.Altern Med Rev. 1999 Oct;4(5):330-41. Review. Naghii MR.The significance of dietary boron, with particular reference to athletes.Nutr Health. 1999;13(1):31-7. Review. Sayli BS.An assessment of fertility in boron-exposed Turkish subpopulations: 2. Evidence that boron has no effect on human reproduction.Biol Trace Elem Res. 1998 Winter;66(1-3):409-22. Penland JG.The importance of boron nutrition for brain and psychological function.Biol Trace Elem Res. 1998 Winter;66(1-3):299-317. Review. Lanoue L, Taubeneck MW, Muniz J, Hanna LA, Strong PL, Murray FJ, Nielsen FH, Hunt CD, Keen CL.Assessing the effects of low boron diets on embryonic and fetal development in rodents using in vitro and in vivo model systems.Biol Trace Elem Res. 1998 Winter;66(1-3):271-98. Fort DJ, Propst TL, Stover EL, Strong PL, Murray FJ.Adverse reproductive and developmental effects in Xenopus from insufficient boron.Biol Trace Elem Res. 1998 Winter;66(1-3):237-59. Samman S, Naghii MR, Lyons Wall PM, Verus AP.The nutritional and metabolic effects of boron in humans and animals.Biol Trace Elem Res. 1998 Winter;66(1-3):227-35. Review. Hunt CD.Regulation of enzymatic activity: one possible role of dietary boron in higher animals and humans.Biol Trace Elem Res. 1998 Winter;66(1-3):205-25. Review. Sutherland B, Strong P, King JC.Determining human dietary requirements for boron.Biol Trace Elem Res. 1998 Winter;66(1-3):193-204. Hunt CD, Herbel JL, Nielsen FH.Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations. Am J Clin Nutr. 1997 Mar;65(3):803-13. Wilson JH, Ruszler PL.Effects of boron on growing pullets.Biol Trace Elem Res. 1997 Mar;56(3):287-94. 28: Naghii MR, Samman S. The effect of boron supplementation on its urinary excretion and selected cardiovascular risk factors in healthy male subjects. Biol Trace Elem Res. 1997 Mar;56(3):273-86. Naghii MR, Wall PM, Samman S. The boron content of selected foods and the estimation of its daily intake among free-living subjects.J Am Coll Nutr. 1996 Dec;15(6):614-9. Meacham SL, Taper LJ, Volpe SL. Effect of boron supplementation on blood and urinary calcium, magnesium, and phosphorus, and urinary boron in athletic and sedentary women. Am J Clin Nutr. 1995 Feb;61(2):341-5. Hunt CD. The biochemical effects of physiologic amounts of dietary boron in animal nutrition models. Environ Health Perspect. 1994 Nov;102 Suppl 7:35-43. Review. Penland JG. Dietary boron, brain function, and cognitive performance. Environ Health Perspect. 1994 Nov;102 Suppl 7:65-72. Newnham RE. Essentiality of boron for healthy bones and joints. Environ Health Perspect. 1994 Nov;102 Suppl 7:83-5. Meacham SL, Taper LJ, Volpe SL. Effects of boron supplementation on bone mineral density and dietary, blood, and urinary calcium, phosphorus, magnesium, and boron in female athletes. Environ Health Perspect. 1994 Nov;102 Suppl 7:79-82. Hunt CD, Herbel JL, Idso JP.Dietary boron modifies the effects of vitamin D3 nutrition on indices of energy substrate utilization and mineral metabolism in the chick. J Bone Miner Res. 1994 Feb;9(2):171-82. Nielsen FH. New essential trace elements for the life sciences.Biol Trace Elem Res. 1990 Jul-Dec;26-27:599-611. Massie HR, Whitney SJ, Aiello VR, Sternick SM. Changes in boron concentration during development and ageing of Drosophila and effect of dietary boron on life span. Mech Ageing Dev. 1990 Mar 31;53(1):1-7. Nielsen FH, Hunt CD, Mullen LM, Hunt JR. Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women.FASEB J. 1987 Nov;1(5):394-7.
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