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Biomarkers of AgingTypically, in anti aging regimens, these biomarkers are used to benchmark how successful the anti aging lifestyle has been. Most use biomarkers of aging as benchmarks. For example, the secretion of many hormones drop as people age. The levels of those hormones act as one type of biomarkers for aging. Then, those on anti aging regimens may try to keep the essential hormones at youthful levels. That is why measuring and comparing the levels of the biomarkers act as a measure to compare current results of the anti aging program to those results that are desirable. Biomarkers are also used in clinical trials as markers for how successful the new treatment is on aging. This is because the human lifespan is so long, and most scientists consider the biomarkers sufficiently reliable markers for effects on total lifespan. Currently, there is a long list of biomarkers that can be used to measure aging or the benefits of an anti aging lifestyle, including
Note that not all the above biomarkers are directly linked to aging, but are considered biomarkers for measuring the successes of an anti aging regimens and a healthy lifestyle that is associated with life extension. You may find a long list of other measures that could be helpful in measuring how successful an anti aging regimen is. Biomarkers of Aging - StudiesNeuroactive steroids: new biomarkers of cognitive aging. Vallee M, Purdy RH, Mayo W, Koob GF, Le Moal M. J Steroid Biochem Mol Biol. 2003 Jun;85(2-5):329-35. Biomarkers of aging in women and the rate of longitudinal changes. Ueno LM, Yamashita Y, Moritani T, Nakamura E. J Physiol Anthropol Appl Human Sci. 2003 Jan;22(1):37-46p. Use of mathematical models of survivorship in the study of biomarkers of aging: the role of heterogeneity. Piantanelli L, Rossolini G, Basso A, Piantanelli A, Malavolta M, Zaia A. Mech Ageing Dev. 2001 Sep 15;122(13):1461-75. Strategy for identifying biomarkers of aging in long-lived species. Ingram DK, Nakamura E, Smucny D, Roth GS, Lane MA. Exp Gerontol. 2001 Jul;36(7):1025-34. Biomarkers of aging: prediction of longevity by using age-sensitive T-cell subset determinations in a middle-aged, genetically heterogeneous mouse population. Miller RA. J Gerontol A Biol Sci Med Sci. 2001 Apr;56(4):B180-6. Behavioral biomarkers of aging: illustration of a multivariate approach for detecting age-related behavioral changes. Markowska AL, Breckler SJ. J Gerontol A Biol Sci Med Sci. 1999 Dec;54(12):B549-66. Growth curves and survival characteristics of the animals used in the Biomarkers of Aging Program. Turturro A, Witt WW, Lewis S, Hass BS, Lipman RD, Hart RW. J Gerontol A Biol Sci Med Sci. 1999 Nov;54(11):B492-501. Lesion biomarkers of aging in B6C3F1 hybrid mice. Lipman RD, Dallal GE, Bronson RT. J Gerontol A Biol Sci Med Sci. 1999 Nov;54(11):B466-77. Immunohistochemical and ELISA assays for biomarkers of oxidative stress in aging and disease. Onorato JM, Thorpe SR, Baynes JW. Ann N Y Acad Sci. 1998 Nov 20;854:277-90. A strategy for identifying biomarkers of aging: further evaluation of hematology and blood chemistry data from a calorie restriction study in rhesus monkeys. Nakamura E, Lane MA, Roth GS, Ingram DK. Exp Gerontol. 1998 Aug;33(5):421-43. Biomarkers of age and aging. McClearn GE. Exp Gerontol. 1997 Jan-Apr;32(1-2):87-94. Candidate biomarkers of aging: age-sensitive indices of immune and muscle function covary in genetically heterogeneous mice. Miller RA, Bookstein F, Van der Meulen J, Engle S, Kim J, Mullins L, Faulkner J. J Gerontol A Biol Sci Med Sci. 1997 Jan;52(1):B39-47. Plasma proteins as biomarkers of the aging process. Vranckx R, Savu L, Lambert N, de Conchard GV, Grosse R, Mourey MS, Corman B. Am J Physiol. 1995 Feb;268(2 Pt 2):R536-48. Biomarkers of aging: correlation of DNA I-compound levels with median lifespan of calorically restricted and ad libitum fed rats and mice. Randerath K, Zhou GD, Hart RW, Turturro A, Randerath E. Mutat Res. 1993 Dec;295(4-6):247-63. The reliability and stability of biomarkers of aging. McClearn GE. Ann N Y Acad Sci. 1992 Dec 26;673:1-8. Biological and functional definition of the older patient: the role of biomarkers of aging. Mooradian AD. Oncology (Huntingt). 1992 Feb;6(2 Suppl):39-44. Neurobehavioral biomarkers of aging: influence of genotype and dietary restriction. Forster MJ, Lal H. Biomed Environ Sci. 1991 Jun;4(1-2):144-65. Biomarkers of aging: do we know what to look for? Mooradian AD. J Gerontol. 1990 Nov;45(6):B183-6. Biomarkers of aging: tissue markers. Future research needs, strategies, directions and priorities. Harrison DE, Archer JR. Exp Gerontol. 1988;23(4-5):309-25. Cellular biomarkers of aging. Cristofalo VJ. Exp Gerontol. 1988;23(4-5):297-307. Key questions in developing biomarkers of aging. Ingram DK. Exp Gerontol. 1988;23(4-5):429-34.
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