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Aubrey de GreyIn order to achieve the goal of ending human aging, according to the scientist, there are 7 areas of the aging process that need to be addressed medically. The seven areas are: 1. Nuclear Mutations/Epimutations In order to expedite research in these areas of aging process, he has (together with David Gobel) founded Methuselah Foundation and the related Methuselah Mouse Prize, which awards monetary prizes to researchers who extend the lifespan of mice to unprecedented lengths. de Grey has published a lot of material on anti aging therapies, including the book "The Mitochondrial Free Radical Theory of Aging" (ISBN 1-58706-155-4). In the book, one of the central claims is that obviating damage to mitochondria might by itself extend lifespan significantly. Aubrey de Grey - Published Researchde Grey ADNJ. The foreseeability of real anti-aging medicine. In: Anti-Aging Medical Therapeutics, volume 7 (R. Klatz, ed.), American Academy for Anti-Aging Medicine, 2005, pp. 59-68. de Grey ADNJ. Escape velocity: why the prospect of extreme human life extension matters now. PLoS Biol 2004; 2(6):723-726. de Grey ADNJ. An engineer's approach to the development of real anti-aging medicine. Science's SAGE KE 2003; 2003(1):vp1. The Fountain of Youth: Ethical, Religious, and Existential Perspectives on a Biomedical Goal (S.G. Post and R.H. Binstock, eds.), Oxford University Press, 2003, pp. 249-267. de Grey ADNJ, Ames BN, Andersen JK, Bartke A, Campisi J, Heward CB, McCarter RJM, Stock G. Time to talk SENS: critiquing the immutability of human aging. In: Increasing Healthy Life Span: Conventional Measures and Slowing the Innate Aging Process - Ninth Congress of the International Association of Biomedical Gerontology (D. Harman, ed.), Annals NY Acad Sci 2002; 959:452-462. de Grey ADNJ. An engineer's approach to the development of real anti-aging medicine. Science's SAGE KE 2003; 2003(1):vp1. Also in: The Fountain of Youth: Ethical, Religious, and Existential Perspectives on a Biomedical Goal (S.G. Post and R.H. Binstock, eds.), Oxford University Press, 2004, pp. 249-267. de Grey ADNJ. Challenging but essential targets for genuine anti-ageing drugs. Expert Opinion on Therapeutic Targets 2003; 37(1):1-5. de Grey ADNJ. UK research on the biology of aging -- the next ten years. Lifespan 2003; 11(1):1-4. de Grey ADNJ. Foreseeable and more distant rejuvenation therapies. In: Aging Interventions and Therapies (S.I.S. Rattan, ed.), World Scientific, 2005, pp. 379-395. de Grey ADNJ. The foreseeability of real anti-aging medicine. In: Anti-Aging Medical Therapeutics, volume 7 (R. Klatz, ed.), American Academy for Anti-Aging Medicine, 2005, pp. 59-68. de Grey ADNJ. A strategy for postponing aging indefinitely. Studies in Health Technology and Informatics 2005; 118:209-219. de Grey ADNJ. Strategie per un invecchiamento transcurabile ingegnerizzato. In: Alterando il destino dell'umanità (Donghi P, ed.), Proceedings of the 2005 Spoletoscienza conference. Rome: Laterza & Figli, 2006, pp. 49-63. Translation by Bruna Tortorella. de Grey ADNJ. Gerontologists and the media: the dangers of over-pessimism. Biogerontology 2000;1(4):369-370. de Grey ADNJ, Gavrilov L, Olshansky SJ, Coles LS, Cutler RG, Fossel M, Harman SM. Antiaging technology and pseudoscience. Science 2002; 296(5568):656. de Grey ADNJ, Baynes JW, Berd D, Heward CB, Pawelec G, Stock G. Is human aging still mysterious enough to be left only to scientists? BioEssays 2002; 24(7):667-676. de Grey ADNJ. Fear of misrepresentation cannot justify silence about foreseeable life-extension biotechnology. BioEssays 2003; 25(1):94-95. de Grey ADNJ. The foreseeability of real anti-aging medicine: focusing the debate. Exp Gerontol 2003; 38(9):927-934. de Grey ADNJ. Biogerontologists' duty to discuss timescales publicly. Annals NY Acad Sci 2004; 1019:542-545. de Grey ADNJ. Escape velocity: why the prospect of extreme human life extension matters now. PLoS Biol 2004; 2(6):723-726. de Grey ADNJ. The war on aging. In: The Scientific Conquest of Death (B.J. Klein et al., eds.), Libros en Red, 2004, pp. 17-29. PDF Also translated into Spanish by Ana Centeno: "La guerra contra el envejecimiento". de Grey ADNJ. Leon Kass: quite substantially right. Rejuvenation Res 2004; 7(2):89-91. de Grey ADNJ. Three self-evident life-extension truths. Rejuvenation Res 2004; 7(3):165-167. de Grey ADNJ. Aging, childlessness or overpopulation: the future's right to choose. Rejuvenation Res 2004; 7(4):237-238. de Grey ADNJ. Life extension, human rights, and the rational refinement of repugnance. J Med Ethics 2005; 31(11):659-663. de Grey ADNJ. Resistance to debate on how to postpone ageing is delaying progress and costing lives. EMBO Rep 2005; 6(S1):S49-S53. de Grey ADNJ. Like it or not, life-extension research extends beyond biogerontology. EMBO Rep 2005; 6(11):1000. de Grey ADNJ. When and where to publish important findings: a casualty of biogerontology's rise to respectability. Rejuvenation Res 2005; 8(1):1-2. de Grey ADNJ. "The rate of aging": a counterproductively undefinable term. Rejuvenation Res 2005; 8(2):77-78. de Grey ADNJ. The ethical status of efforts to postpone aging: a reply to Hurlbut. Rejuvenation Res 2005; 8(3):129-130. de Grey ADNJ. The SENS challenge: $20,000 says the foreseeable defeat of aging is not laughable. Rejuvenation Res 2005; 8(4):207-210. de Grey ADNJ. Compression of morbidity: the hype and the reality, part 1. Rejuvenation Res 2006; 9(1):1-2. de Grey ADNJ. Compression of morbidity: the hype and the reality, part 2. Rejuvenation Res 2006; 9(2):167-168. de Grey ADNJ. Has Hippocrates had his day? Rejuvenation Res 2006; 9(3):371-373. de Grey ADNJ. SENS survives the Challenge; now let's get to work. Rejuvenation Res 2006; 9(4):429-430. de Grey ADNJ. Is SENS a farrago? Rejuvenation Res 2006; 9(4):436-439. de Grey ADNJ. The urgency dilemma: is life extension research a temptation or a test? Update 2006; in press. de Grey ADNJ. Reasons and methods for promoting our duty to extend healthy life indefinitely. J Evol Technol 2006, in press. de Grey ADNJ. Postponing aging: who are the experts? Proceedings of James Martin Institute World Forum 2006, in press. de Grey ADNJ. Are those 13 proteins really unimportable? In: From Symbiosis to Eukaryotism - Endocytobiology VII (E. Wagner et al., eds.), Geneva University Press, 1999, pp. 489-502. de Grey ADNJ. Mitochondrial gene therapy: an arena for the biomedical use of inteins. Trends Biotechnol 2000; 18(9):394-399. de Grey ADNJ. Response to "approaches and limitations to gene therapy for mitochondrial diseases," Antioxid. Redox Signal. 2001;3:451-460. Antioxid Redox Signal 2001; 3(6):1153-1155. de Grey ADNJ. Inter-species therapeutic cloning: the looming problem of mitochondrial DNA and two possible solutions. Rejuvenation Res 2004; 7(2): 95.98. de Grey ADNJ. Forces maintaining organellar genomes: is any as strong as genetic code disparity or hydrophobicity? BioEssays 2005; 27(4):436-446. de Grey ADNJ. Bioremediation meets biomedicine: therapeutic translation of microbial catabolism to the lysosome. Trends Biotechnol 2002; 20(11): 452-455. de Grey ADNJ, Alvarez PJJ, Brady RO, Cuervo AM, Jerome WG, McCarty PL, Nixon RA, Rittmann BE, Sparrow JR. Medical bioremediation: prospects for the application of microbial catabolic diversity to aging and several major age-related diseases. Ageing Res Rev 2005; 4(3):315-338. de Grey ADNJ. Lysosomal enhancement with microbial hydrolases: a novel strategy for removing protein aggregates. In: New Trends in Alzheimer and Parkinson Disorders: ADPD 2005 (A. Fisher et al., eds.), Medimond 2005, pp. 51-54. de Grey ADNJ. Appropriating microbial catabolism: a proposal to treat and prevent neurodegeneration. Neurobiol Aging 2006; 27(4):589-595. de Grey ADNJ, Campbell FC, Dokal I, Fairbairn LJ, Graham GJ, Jahoda CAB, Porter ACG. Total deletion of in vivo telomere elongation capacity: an ambitious but possibly ultimate cure for all age-related human cancers. Annals NY Acad Sci 2004; 1019:147-170. de Grey ADNJ. Whole-body interdiction of lengthening of telomeres: a proposal for cancer prevention. Front Biosci 2005; 10:2420-2429. de Grey ADNJ. Protagonistic pleiotropy: why cancer may be the only pathogenic effect of accumulating nuclear mutations and epimutations in aging. Mech Ageing Dev 2006, in press. de Grey ADNJ. Challenging but essential targets for genuine anti-ageing drugs. Expert Opinion on Therapeutic Targets 2003; 37(1):1-5. de Grey ADNJ. Foreseeable pharmaceutical repair of age-related extracellular damage. Current Drug Targets 2006;7(11):1469-1477. de Grey ADNJ. A proposed refinement of the mitochondrial free radical theory of aging. BioEssays 1997; 19(2):161-166. de Grey ADNJ. A mechanism proposed to explain the rise in oxidative stress during aging. J Anti-Aging Med 1998; 1(1):53-66. de Grey ADNJ. The mitochondrial free radical theory of aging. Austin, TX: Landes Bioscience, 1999, 212pp, hardcover (ISBN 1-57059-564-X). de Grey ADNJ. The non-correlation between maximum longevity and enzymatic antioxidant levels among homeotherms; implications for retarding human aging. J Anti-Aging Med 2000; 3(1):25-36. de Grey ADNJ. The reductive hotspot hypothesis: an update. Arch Biochem Biophys 2000; 373(1):295-301. de Grey ADNJ. The reductive hotspot hypothesis of mammalian aging: membrane metabolism magnifies mutant mitochondrial mischief. Eur J Biochem 2002; 269(8):2003-2009. de Grey ADNJ. Mitochondrial mutations in vertebrate aging. In: Oxidative stress and aging: advances in basic science, diagnostics, and intervention (R.G. Cutler and H. Rodriguez, eds.), World Scientific Publishing, 2002, pp. 437-451. de Grey ADNJ. Mechanisms underlying the age-related accumulation of mutant mitochondrial DNA. In: Genetics of mitochondrial diseases (I.J. Holt, ed.), Oxford University Press, 2003, pp. 247-275. de Grey ADNJ. Mitochondria in homeotherm aging: will detailed mechanisms consistent with the evidence now receive attention? Aging Cell 2004; 3(2):77. de Grey ADNJ. Mitochondrial mutations in mammalian aging: an over-hasty about-turn? Rejuvenation Res 2004; 7(3):171-174. de Grey ADNJ. Reactive oxygen species production in the mitochondrial matrix: implications for the mechanism of mitochondrial mutation accumulation. Rejuvenation Res 2005; 8(1):13-17. de Grey ADNJ. The plasma membrane redox system: a candidate source of aging-related oxidative stress. AGE J Am Aging Assoc 2005; 27(2):129-138. de Grey ADNJ. Free radicals in aging: causal complexity and its biomedical implications. Free Radic Res 2006; 40(12):1244-1249. de Grey ADNJ. Incorporation of transmembrane hydroxide transport into the chemiosmotic theory. Bioelectrochem Bioenerg 1999; 49(1-2):43-50. de Grey ADNJ. Biologists abandon Popper at their peril. BioEssays 2000; 22(2):206-207. de Grey ADNJ. A proposed mechanism for the lowering of mitochondrial electron leak by caloric restriction. Mitochondrion 2001; 1(2):129-139. de Grey ADNJ. UK research on the biology of aging. Exp Gerontol 2001; 37(1):1-7. de Grey ADNJ. Response to "telomere shortening with aging in human liver". J Gerontol A Biol Sci Med Sci 2001; 56(6):B237-B238. de Grey ADNJ. HO2: the forgotten radical. DNA Cell Biol 2002; 21(4):251-257. de Grey ADNJ. Critique of the demographic evidence for "late-life non-senescence". Biochem Soc Trans 2003; 31(2):452-454. de Grey ADNJ. A proposal for the overall structure of the mammalian plasma membrane redox system. Protoplasma 2003; 221(1-2):3-9. de Grey ADNJ. Overzealous maximum-likelihood fitting falsely convicts the slope heterogeneity hypothesis. Exp Gerontol 2003; 38(8):921-923. de Grey ADNJ. Falsifying falsifications: the most critical task of theoreticians in biology. Medical Hypotheses 2004; 62(6):1012-1020. de Grey ADNJ. The unfortunate influence of the weather on the rate of aging: why human caloric restriction or its emulation may only extend life expectancy by 2-3 years. Gerontology 2005; 51(2):73-82. de Grey ADNJ. Extrapolaholics Anonymous: why demographers' rejections of a huge rise in cohort life expectancy in this century are overconfident. Annals NY Acad Sci 2006; 1067:83-93. de Grey ADNJ. Gene therapy. In: Encyclopedia of Aging, Fourth Edition (R. Schulz et al., eds.), Springer, 2006, in press.
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