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Ascorbyl PalmitateSince ascorbyl palmitate is a fat-soluble derivative of ascorbic acid, theoretically this means that it can concentrate into the lipid domains of biological systems and protect cell membranes and low density lipoproteins (LDL) against oxidation. This also means that if ascorbyl palmitate is absorbed intact, it may be expected to be a better antioxidant in the lipid domains of the cell membranes and in LDL than is ascorbic acid. Also, it may be expected to be a more efficient partner with d-alpha-tocopherol than is ascorbic acid with regard to sparing vitamin E, as well as regenerating it from its radical form. However, to date, little is known of the pharmacokinetics of ascorbyl palmitate and more research is needed. Ascorbyl Palmitate - StudiesKaneko T, Kaji K, Matsuo M. Protective effects of lipophilic derivatives of ascorbic acid on lipid peroxide-induced endothelial injury. Arch Biochem Biophys. 1993; 304:176-180. Perricone N, Nagy K, Horvath F, et al. The hydroxyl free radical reactions of ascorbyl palmitate as measured in various in vitro models. Biochem Biophys Res Commun. 1999; 262:661-665.
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