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Anti Wrinkle InjectionsMuch of the causes of facial wrinkles and creases appear as the under-lying collagen and elastin fibers begin to break down and wear out, which results in the appearance of droopy and wrinkled skin. To counterbalance the loss of skin's own natural fillers, there are several injectable fillers that aim to rejuvenate the skin either permanently or temporarily. Injectable wrinkle fillers include fat grafts (from your own body), bovine collagen-based fillers such as Zyderm & Zyplast, Artecoll, Fascian, Cymetra, AlloDerm, and human collagen fillers such as CosmoDerm and CosmoPlast. Hyaluronic acid fillers include Hylaform, Restylane and Perlane. Hydroxylapatite fillers include Radiance. Another one is called Microdroplet Liquid Silicone, used in some practices. Another injectable anti wrinkle operation is Botox, which is a formulation of botulinum toxin type A, derived from the bacterium Clostridium botulinum. On April 15, 2002, U.S. FDA approved botulinum toxin type A (BOTOX Cosmetic) to temporarily improve the appearance of moderate-to-severe frown lines between the eyebrows. In studies, indications have been that Botox reduces the severity of frown lines for up to 120 days. Anti Wrinkle Injections - StudiesA multicenter, double-blind, randomized, placebo-controlled study of the efficacy and safety of botulinum toxin type A in the treatment of glabellar lines. Carruthers JA, Lowe NJ, Menter MA, Gibson J, Nordquist M, Mordaunt J, Walker P, Eadie N. J Am Acad Dermatol. 2002 Jun;46(6):840-9. Botox for the Treatment of Dynamic and Hyperkinetic Facial Lines and Furrows: Adjunctive Use in Facial Aesthetic Surgery. Fagien, Steven. Plastic & Reconstructive Surgery. 112(5) Supplement:40S-52S, October 2003. Temporal Brow Lift Using Botulinum Toxin A. Ahn, Min S., Catten, Michael, and Maas, Corey. Plastic & Reconstructive Surgery. 112(5) Supplement:98S-104S, October 2003. Collagen and injectable fillers. Cheng JT, Perkins SW, Hamilton MM. Otolaryngol Clin North Am. 2002 Feb;35(1):73-85, vi. Collagen fillers. Baumann L, Kaufman J, Saghari S. Dermatol Ther. 2006 May-Jun;19(3):134-40. Collagen-containing fillers: alone and in combination. Baumann L. Clin Plast Surg. 2006 Oct;33(4):587-96.
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