Aminoguanidine

Aminoguanidine has been suggested to actively inhibit glycosylation, or cross-linking of proteins, which has been associated as one of the causes of aging.

In one animal study, the compound prevented age-related enlargement of the heart, and the membrane surface area of the heart was reduced by 30%.

Furthermore, the collagen content of the heart's arterial walls was increased by 24-30%.

From cardiovascular disease prevention viewpoint, studies by University of Milan have shown the compound's potential to reduce the ability of LDL ("bad") cholesterol to bind itself to blood vessel walls.

Most importantly from anti aging viewpoint, the compound has proven potential to slow the aging process by protecting skin proteins (collagen and elastin), eye lens protein, nerve protein and kidney proteins from the aging process.

Aminoguanidine - Studies

Hipkiss AR. On the anti-aging activities of aminoguanidine and N-t-butylhydroxylamine. Mech Ageing Dev 2001, 122 (2): 169-171.

Giardino I, Fard AK, Hatchell DL, Brownlee M. Aminoguanidine inhibits reactive oxygen species formation, lipid peroxidation, and oxidant-induced apoptosis. Diabetes. 1998 Jul;47(7):1114-20.

Chen AS, Taguchi T, Aoyama S, Sugiura M, Haruna M, Wang MW, Miwa I. Antioxidant activity of a Schiff base of pyridoxal and aminoguanidine. Free Radic Biol Med. 2003 Dec 1;35(11):1392-403.

Ihm SH, Yoo HJ, Park SW, Ihm J. Effect of aminoguanidine on lipid peroxidation in streptozotocin-induced diabetic rats. Metabolism. 1999 Sep;48(9):1141-5.


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