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5-LoxinAccording to studies, the compound should be taken together with nexrutine, another plant based substance that inhibits Cox-2 enzyme, for maximum effectiveness. The boswellia plant has been traditionally used in Ayurvedic medicine, and studies have shown that it is effective for promoting joint and knee health. Other compounds that have been associated with joint health in studies include MSM, Glucosamine, and Chondroitin. 5-Loxin - StudiesSafety and toxicological evaluation of a novel, standardized 3-o-acetyl-11-keto-beta-boswellic acid (AKBA)-enriched boswellia serrata extract (5-Loxin). Lalithakumari K, Krishnaraju AV, Sengupta K, Subbaraju GV. Toxicology Mechanisms and Methods. 2006:16;199-226. Roy S, Khanna S, Shah H, et al. Human genome screen to identify the genetic basis of the anti-inflammatory effects of Boswellia in microvascular endothelial cells. DNA Cell Biol. 2005 Apr;24(4):244-55. Safayhi H, Sailer ER, Ammon HP. Mechanism of 5-lipoxygenase inhibition by acetyl-11-keto-beta-boswellic acid. Mol Pharmacol. 1995 Jun;47(6):1212-6. Sailer ER, Subramanian LR, Rall B, Hoernlein RF, Ammon HP, Safayhi H. Acetyl- 1 keto-beta-boswellic acid (AKBA): structure requirements for binding and 5-lipoxygenase inhibitory activity. Br J Pharmacol. 1996 Feb;117(4):615-8.
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